IndraLab

Statements

All-trans-retinoic acid increases the amount of TNFAIP3. 2 / 2
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"In contrast, ATRA induces the expression of BIRC3 and TNFAIP3, which inhibit Fas and TNFalpha mediated apoptosis signaling pathway by the interaction with TRAF2, and thus may prevent apoptosis."
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"However, fenretinide specifically induced Fas and TNFalpha mediated apoptosis by increasing the expression of pro apoptotic genes i.e., DEDD2, CASP8, CASP4, and HSPA1A/B; whereas, ATRA induced the expression of BIRC3 and TNFAIP3, which inhibit apoptosis by interacting with TRAF2."
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