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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

All-trans-retinoic acid increases the amount of TNFAIP3. 2 / 2

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"In contrast, ATRA induces the expression of BIRC3 and TNFAIP3, which inhibit Fas and TNFalpha mediated apoptosis signaling pathway by the interaction with TRAF2, and thus may prevent apoptosis."

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"However, fenretinide specifically induced Fas and TNFalpha mediated apoptosis by increasing the expression of pro apoptotic genes i.e., DEDD2, CASP8, CASP4, and HSPA1A/B; whereas, ATRA induced the expression of BIRC3 and TNFAIP3, which inhibit apoptosis by interacting with TRAF2."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...