IndraLab

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ZUP1 deubiquitinates DDX58. 2 / 2
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"USP3 is also a DUB that deubiquitinates K63-polyUb chain of both RIG-I and MDA5 and suppresses IFN-β activation [25]."
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"However, nairoviruses, like arterviruses, encode DUB enzymes that deubiquitinate RIG-I to prevent innate immune signaling activation (van Kasteren et al., 2012), suggesting that during nairovirus infection/replication a PAMP, likely a viral transcription product, is produced that can activate RIG-I."
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