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SOS increases the amount of USP25. 1 / 1
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"HEK-293T cells were transfected with ISRE reporter plasmid USP25 Negatively Regulates Type I IFN Signaling PLOS ONE | www.plosone.org The results suggest that overexpression of USP25 strongly inhibited SEV-induced activation of ISRE promoter in a dosedependent manner ( Figure 1B) ."