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Ischemia increases the amount of USP18. 2 / 2
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"As an in vivo correlate of our in vitro findings, experimentally induced hepatic ischemia/reperfusion injury induced USP18 mRNA expression in liver and enhanced lymphocytic choriomeningitis (LCMV) replication, an effect not seen in USP18−/− mice."

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"Error bars represent the SEM for duplicate PCRs.FIG 6: Experimental hepatic ischemia/reperfusion induces USP18 expression and enhances LCMV replication."