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SRC activates RAC1. 70 / 77
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"We demonstrate that the PI 3-kinase and Src kinase signaling pathways converge to activate Rac1 and JNK."
9799234
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"Importantly, inhibition of Src decreased efferocytosis and Rac1 activation in WT cells."
26059978
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"In this study, we demonstrated that ITGA9 reduced the FAK and Src phosphorylation, decreased Rac1 and RhoA activation, and promoted focal adhesion maturation, leading to the suppression of HCC cell motility."
29951557
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"In the HT29 human colon carcinoma cell line, Src induced Nox2 -mediated ROS production by activating the regulatory subunit small GTPase Rac1 [56]."
28978491
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"Requirement for Y724 phosphorylation of ELMO1 in Src-dependent Rac1 activation."
26205662
sparser
"As an activation of Src leads to an elevation of the complex consisting of p130 Cas /Crk/Dock180 in breast cancer cells [ xref ], ELMO1/Dock180 binding must be important for producing Src-dependent activation of Rac1."
26205662
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"Collectively, these data suggest that CiaC contributes to Rac1 membrane recruitment and activation, and that maximal C. jejuni invasion of host cells is dependent Rac1 activity that is induced, in part, by EGFR, FAK, PI3 kinase, and Src activation."
21999233
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"Additionally, recent reports highlighted the role of mDia1 in v-Src kinase membrane translocation and in c-Src mediated activation of Rac1 upon EGF stimulation."
22511750
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"The role of p130cas in migration depends largely on its tyrosine phosphorylation by FAK and Src family kinases (SFKs) after growth factor receptor or integrin activation (by BDNF and collagen, respectively, in our assays) and assembly of the p130cas-Crk-DOCK180 scaffold, which drives localized Rac1 and MAPK activation XREF_BIBR, XREF_BIBR, XREF_BIBR."
23785422
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"Our observation may provide an additional molecular mechanism underlying the Src mediated local activation of Rac1."
26205662
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"Furthermore, addition NC to cells significantly decreases PDGF induced phosphorylation of c-Src, FAK, MAPKs, activation of RhoA, Rac1 and AP-1 transcriptional activity."
21959111
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"In support of our data, it was reported that active c-Src can phosphorylate and potentiate Tiam1, a guanine nucleotide exchange factor (GEF) which exhibits the highest specificity for Rac1, indicating that Rac1 is mainly activated by c-Src via Tiam1 XREF_BIBR."
27881869
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"However, another proleakage mediator, namely, VEGF-165 (the predominant isoform of VEGF A) causes Src family kinase (SFK) dependent activation of Rac-1 that ends up in increased permeability [XREF_BIBR, XREF_BIBR]."
22084722
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"It was previously reported that the interaction of active Src with Vav2 causes Vav2 activation and promotes the activation of Rac1 [51, 52]."
29964204
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"We show that by interacting with NIS at the PM, adherens junction (AJ)-associated P120-catenin recruits and is phosphorylated by SRC, allowing it to recruit RAC1 to the complex."
36358781
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"M-CSF signaling via Src up-regulated Rac1 activity but down-regulated Rho activity."
25056912
sparser
"Taking these findings together with the fact that SRC activity was required for HGF-induced RAC1 activation ( xref , E and F ), it is likely that HGF-induced RAC1 activation by CDCP1-SRC is preferentially dependent on ARHGEF7, raising the next question of how the CDCP1-SRC axis activates ARHGEF7."
35085554
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"In addition, inhibition of Src with its selective inhibitor PP2 and shRNA targeted to Src blocked Rac1 signal activation (p < 0.05 for each), but inhibition of the activity of PLCgamma1 did not affect the phosphorylation and activation levels of Rac1 under conditions of periodic mechanical stress."
22890232
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"Our results also indicate that signaling events downstream of EGF receptor involved PI3K- and Src dependent activation of Rac1, which mediated the NADPH generated reactive oxygen species responsible for MMP-2 secretion and activation."
19116140
sparser
"Src-dependent activation of Rac1 is essential for VEGF induced endothelial cell migration and permeability [ xref , xref ]."
24689049
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"A recent report also suggests that ribosome protein S6 kinase (S6K1) and its upstream regulator mTOR play a role in stimulating Src dependent activation of Rac1 through association with the Rac1-GEF Tiam1 [XREF_BIBR]."
22980731
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"Thus, it is likely that c-Src enhances Rac1 activity cooperatively through both activation of positive regulators of Rac1 (Rac-GEFs) and inhibition of a negative regulator of Rac1 (beta2-chimaerin Rac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17560670
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"In vascular smooth muscle cells, activation of the angiotensin AT 1 receptor leads to phosphorylation of p47 phox [XREF_BIBR] and Src mediated Rac1 translocation to the membrane which result in Nox1 activation in aortic VSMC [XREF_BIBR]."
18760347
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"However, for quantitative parameter estimation for the Src activation coupling it was necessary to use a course fitting to other experimental data, see Appendix.In the model, the resulting Src activat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21439300
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"Src dependent activation of Rac1 is essential for VEGF induced endothelial cell migration and permeability [XREF_BIBR, XREF_BIBR]."
24689049
sparser
"A recent report also suggests that ribosome protein S6 kinase (S6K1) and its upstream regulator mTOR play a role in stimulating Src-dependent activation of Rac1 through association with the Rac1-GEF Tiam1 [ xref ]."
22980731
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"As neither CD147 nor Src is a GEF or GAP, Rac1 activity can not be directly regulated by CD147 or Src."
25428919
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"Src was also shown to increase Rac1 activity through the PI3 kinase pathway and promote E-cadherin adhesion XREF_BIBR, XREF_BIBR; however, given the fact that CD148 dephosphorylates the p85 regulatory subunit and reduces PI3 kinase activity XREF_BIBR, this mechanism would be less contributory."
25386896
sparser
"These results indicate that PI3K and Src synergistically activated Rac1 upon EGF stimulation in PANC-1 cells."
19116140
sparser
"Thus, these results indicate that the resistance mechanisms driven by knockdown of CUL3 involve the reestablishment of MAPK signaling as a result of the stabilization and Src-dependent activation of RAC1."
32346533
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"Importantly, protein kinase C and c-Src can also activate the small GTPase Rac1 through downstream phosphorylation of GDP to GTP ( xref ; xref ; xref ; xref )."
33519510
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"Integrin alpha2beta1 recruitment triggered the Src kinase independent activation of the small GTPase Rac1, and activation of Rac1 was not required for PLCgamma2 phosphorylation."
19422462
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"ROS generation, Rac1 activation, and p67 (phox) membrane translocation were also prevented by Src inhibition."
20380579
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"In VEGF stimulated ECs, Src mediates Rac1 activation, leading to VE-cadherin phosphorylation via the serine/threonine kinase PAK, and thereby increasing endothelial permeability XREF_BIBR."
28602626
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"In human pancreatic cancer cells, epidermal growth factor (EGF) induces the secretion and activation of MMP-2 through an intracellular signaling pathway that involves PI3K- and Src dependent activation of Rac1, which, in turn, is responsible for the NOX mediated ROS production [XREF_BIBR]."
24281116
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"Importantly, protein kinase C and c-Src can also activate the small GTPase Rac1 through downstream phosphorylation of GDP to GTP."
33519510
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"On the other hand, Rac1 may be activated in adhesion sites through Src and PI3K, which activate Rac1 GEFS."
18253510
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"These results indicate that PI3K and Src synergistically activated Rac1 upon EGF stimulation in PANC-1 cells.Rac GTPase is the upstream signal protein for nicotinamide adenine dinucleotide phosphate ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19116140
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"As an activation of Src leads to an elevation of the complex consisting of p130 Cas / Crk and Dock180 in breast cancer cells [XREF_BIBR], ELMO1 and Dock180 binding must be important for producing Src dependent activation of Rac1."
26205662
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"Flii overexpressing fibroblasts also have a significantly reduced ratio of activated p130Cas, with decreased expression of Src tyrosine kinase, both known to be involved in the Src mediated activation of Rac1 and Cdc42, phosphorylation of paxillin and subsequent membrane protrusion."
33330501
sparser
"Importantly, protein kinase C and c-Src can also activate the small GTPase Rac1 through downstream phosphorylation of GDP to GTP (Figure 1; Harrison et al., 2003; Ohtsu et al., 2006; Gianni et al., 2008)."
33519510
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"Furthermore, the expression of mitochondrial SOD in fibrosarcoma cells increases the levels of MMP-1 and the incidence of experimental pulmonary metastasis [XREF_BIBR], a n d t h e secretion and activation of MMP2 downstream of EGF signaling in pancreatic cancer cells is dependent on NADPH generated ROS mediated by PI3K- and Src dependent activation of Rac1 [XREF_BIBR]."
22033009
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"PG-/- cells also exhibited Src independent activation of the small GTPases Rac1 and RhoA."
20876660
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"These results suggested that Src promotes the Rac1 signaling pathway but inhibits the RhoA signaling pathway in cytoskeletal rearrangement and cell movement in HCC cells, a role similar to that of CD147."
25428919
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"Previous reports have identified that down-regulation of caveolin-1 increases Src activation, which activates Rac1 through the exchange factors Dock180 XREF_BIBR, Tiam1, Vav2 XREF_BIBR, and FRG (through Cdc42 and Vav2) XREF_BIBR."
23383114
eidos
"It was later reported that EGFRvIII , a constitutively active EGFR mutant , stimulates the phosphorylation of Dock180 via Src , which stimulates Rac1 signaling , glioblastoma cell survival , and migration [ 68 ] ."
30544910
sparser
"These results suggest that L1 promotes neurite formation and branching by activating Src and Vav2 GEF dependent activation of Rac1."
20298788
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"Tao et al demonstrated that macrophage SR-BI bound to PS and induced Src phosphorylation, which led to the activation of the downstream molecules PI3K and Rac1, phagocytosis and elimination of apoptotic cells in atherosclerotic lesions, thereby reducing necrosis, inhibiting inflammatory responses and exerting an anti-atherosclerotic effect."
| PMC
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"Studies have shown that Src activation induces Rac1 activity and that PI3K activity is important for phagosome formation via the Fcgamma receptor."
26059978
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"SRC phosphorylation activates Rac1 proteins responsive to tissue factor-induced cellular apoptosis in endothelial cells [51]."
35062973
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"Single substitution of Y724 to Phe abrogated Rac1 activation triggered by Src."
26205662
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"In addition to its role in phosphorylation of p47 phox, c-Src activation also stimulates the transactivation of the epidermal growth factor receptor (EGFR), which evokes phosphatidylinositol 3-kinase-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12967772
sparser
"Src-dependent activation of Rac1 was studied in the context of glioma tumorigenesis ( xref )."
31510678
sparser
"CUL3 was recently shown to enhance MAPK signaling by stabilization and Src-dependent activation of RAC1 ( xref )."
33604667
sparser
"Src-induced Rac1 activation results in the generation of reactive oxygen species (ROS), which are involved in various cellular receptor signal transduction pathways."
32456226
signor
"N attractive hypothesis consistent with our present data is that the gef responsible for rac activation in mce cells may be activated by src family kinase tyrosine phosphorylationour results present a novel mechanism by which the pi3k and src signaling cascades cooperate to activate rac and promote intestinal epithelial cell migration downstream of egfr."
17991704
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"CD147 promotes Src dependent activation of Rac1 signaling through STAT3 and DOCK8 during the motility of hepatocellular carcinoma cells."
25428919
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"VEGF stimulation of endothelial cells activates Src, which stimulates Vav2, Rac1, and its downstream effector PAK1."
24044891
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"Collectively, our study identifies the loss of CUL3 as a driver of MAPKi resistance through activation of RAC1 and demonstrates that inhibition of the Src family can suppress the MAPKi resistance phenotype in CUL3 KD cells by inactivating RAC1 protein."
32346533
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"Our results also indicate that the signaling events downstream of EGFR involved activation of PI3K and Src, which synergistically activated Rac1."
19116140
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"Inhibition of c-Src by pretreatment with Src family kinase inhibitor PP2 or small interfering RNA targeting of c-Src attenuated radiation induced p38 MAPK and Rac1 activation and enhanced Bax and Bak activation and cell death."
19010820
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"In addition, Src activates PI3K/AKT via Axl, and Rac1/PAK."
35634305
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"We therefore speculated that the activation of Src may activate Cdc42 and Rac1 through beta-Pix/GIT1/PLCgamma1 complexes and promote actin reorganisation."
27824116
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"Further, Src was shown to activate Rac1 through the guanine exchange factor Vav2 and promote E-cadherin adhesion XREF_BIBR."
25386896
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"CUL3 was recently shown to enhance MAPK signaling by stabilization and Src dependent activation of RAC1."
33604667
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"Taken together, we identified that Src and Vav2 activation mediated the EMP1-induced enhancement of Rac1 activity and cell migration, concomitant with copine-III."
29867202
sparser
"Our results also indicate that signaling events downstream of EGF receptor involved PI3K- and Src-dependent activation of Rac1, which mediated the NADPH-generated reactive oxygen species responsible for MMP-2 secretion and activation."
19116140
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"In addition, we found that Src activation could enhance Rac1 activity and F-actin accumulation that typify microglial phagocytic activity."
22989325
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"Src kinase and PI3-kinase signalling pathways converge to activate Rac1 and JNK after SCF stimulation in BMMC, promoting cell proliferation (Timokhina et al., 1998)."
16483568
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"On the other hand, Rac1 may be activated in adhesion sites through Src and PI3K, which activate Rac1 GEFS."
18253510