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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

LPA inhibits KCNK18. 2 / 2

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"Now application of 2 μM LPA totally abolished TRESK current augmentation (n = 12; Fig 2D, lower trace) indicating that this step of signal transduction is essential to regulate TRESK channels by endogenous LPA receptors.In further experiments we took advantage of endogenously expressed LPA receptors that are necessary and sufficient to regulate TRESK channels."

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"It is yet to be clarified under which scenario LPA can effectively produce pain by bypassing the inhibitory activity of TRESK channels."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...