IndraLab

Statements

USP11 activates XIAP. 2 / 3
| 2
reach
"While we have identified the critical role of UPS11 in mammary tumorigenesis and further dissected the mechanism by which USP11 catalyzes XIAP for deubiquitylation, the mechanism that initiates the accumulation of USP11 in breast cancer tissue and its subsequent regulation during the tumor development still remains unknown."
28040451
reach
"We observed that the XIAP expression levels were tightly regulated by USP11, and that elevated expression of USP11 led to significant upregulation of both endogenous and exogenous XIAP, while as the mRNA level of XIAP has no change (XREF_FIG A & B, Supplemental Figs. 1 & 2A)."
28040451