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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP11 activates XIAP. 2 / 3

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"While we have identified the critical role of UPS11 in mammary tumorigenesis and further dissected the mechanism by which USP11 catalyzes XIAP for deubiquitylation, the mechanism that initiates the accumulation of USP11 in breast cancer tissue and its subsequent regulation during the tumor development still remains unknown."

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"We observed that the XIAP expression levels were tightly regulated by USP11, and that elevated expression of USP11 led to significant upregulation of both endogenous and exogenous XIAP, while as the mRNA level of XIAP has no change (XREF_FIG A & B, Supplemental Figs. 1 & 2A)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...