IndraLab

Statements

Vasotocin inhibits OTUB1. 5 / 5
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eidos
"All cell lysates were subjected to WB assays as indicated AVT interferes with the interaction between Otub1 and c-Maf to increase c-Maf polyubiquitination AVT was identified from the Otub1 / c-Maf system , while Otub1 interacts with c-Maf and prevents its polyubiquitination as its deubiquitinase , therefore , we wondered whether AVT can inhibit Otub1 activity toward c-Maf ubiquitination ."
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"It is also in agreement with our hypothesis that AVT inhibits the Otub1 and c-Maf axis therefore leading to MM cell apoptosis and myeloma regression."
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"As shown in Fig. 5b , Otub1 markedly reduced c-Maf polyubiquitination level but it was reversed by AVT , suggesting AVT inhibited Otub1 activity thus increasing the polyubiquitination level of c-Maf ."
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"AVT was identified from the Otub1 and c-Maf system, while Otub1 interacts with c-Maf and prevents its polyubiquitination as its deubiquitinase, therefore, we wondered whether AVT can inhibit Otub1 activity toward c-Maf ubiquitination."
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"The natural product AVT inhibits the Otub1 and c-Maf axis and displays potent anti-myeloma activity."
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