IndraLab

Statements

Mutated TP53 decreases the amount of mutated TP53. 3 / 3
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"Therapeutic strategies in mutant p53 cells include attempts to decrease mutant p53 expression, prevent mutant p53 from binding to target proteins, target downstream signalling molecules, restore the normal folding of the mutant protein or viral delivery of wildtype p53 or perhaps family members (summarised and discussed in [81,82,83])."
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"Given that depletion of mutant p53 and RUNX2 reduces the expression level of RUNX2 and mutant p53, respectively, it is likely that there exists a positive auto-regulatory feedback loop between mutant p53 and RUNX2, and this regulatory system might contribute to the low sensitivity of MiaPaCa-2 cells against SAHA."
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"Interestingly MDA-MB-231, has high levels of a mutant p53 and phospholipase D (PLD) activity, which provides a survival signal in these cells when deprived of serum growth factors (Hui et al., 2006), however in our results, mutant p53 levels is suppressed by all these three extracts.5 Conclusion."
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