IndraLab

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UCHL1 decreases the amount of UCHL1. 7 / 10
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"Furthermore, CRISPR/dCas9-mediated epigenetic editing of UCHL1 (using a catalytically inactivated Cas9) [17] – was employed to up- and downregulate the expression of UCHL1 to further validate these findings."
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"By using immunohistochemistry and Western blot study, we observed that the PGP9.5 increased in sepsis group and MK-801 inhibited the expression of PGP9.5 (Figure 3A)."
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"XREF_BIBR Also, it has been demonstrated that ciRS-7 can repress Alzheimer 's disease (AD) development by suppressing NF-kappaB protein synthesis and inducing its cytoplasmic localization, promoting UCHL1 expression and UCHL1 induced amyloid precursor protein (APP) and BACE1 ubiquitination and degradation."
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"In the present study, we found that the PGP9.5 increased in sepsis group and MK-801 inhibited the expression of PGP9.5."
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"Taken together, these data demonstrate that UCH-L1 inhibition specifically reduced cytoplasmic p27 Kip1 protein content in PHN.As in human and rodent MGN, over-expression of UCH-L1 in cultured podocyt[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Figure 4D, the mRNA levels of USP9x and UCHL1 were significantly upregulated in hepatic CD8 T cells from septic mice, whereas WP1130 treatment inhibited USP9x expression but not UCHL1 expression."
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"To further confirm the role of UCH-L1 in breast cancer cell apoptosis, we used MCF7 and Adr derived cells in which over-expression of UCH-L1 was suppressed by transfection of UCH-L1 siRNA."
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