IndraLab

Statements

CYLD inhibits cell. 4 / 4
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"Our knockout and overexpression results consistently show the CYLD expression inhibits NPC cell proliferation and delays cell transition from early S to G2 phase in the cell cycle in vitro ."
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"Consistent with this , CYLD deficiency causes constitutive activation of TBK1 and IKKepsilon in dendritic cells ."
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"Functional assays revealed CYLD inhibits NPC cell proliferation and migration in vitro and suppresses NPC tumorigenicity and metastasis in vivo by negatively regulating the NF-kB signaling pathway ."
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"Moreover , since CYLD can act as a negative regulator of NF-kappaB pathways [ 48 ] , depressed CYLD expression resulted in aberrant activation of NF-kappaB , thereby inducing HCC cells to express abundantly a neutrophilic chemokine , CXCL5 , which can attract a large number of neutrophils [ 47 ] ."
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