IndraLab
Statements
reach
"Several independent pieces of data suggest a functional relationship between uH2A levels and DISC : (i) expression of an H2A allele that can not be monoubiquitylated at lysine 119 partially rescues transcription (XREF_FIG), (ii) inhibition of the known H2A E3 ubiquitin ligase RNF8 and the related RNF168 partially reverses silencing (XREF_FIG), and (iii) depletion of the uH2A deubiquitylating enzyme USP16 prevents the reversal of silencing and diminution of uH2A at DSBs upon ATMi or cessation of damage."