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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP16 activates His2A. 1 / 1

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"Several independent pieces of data suggest a functional relationship between uH2A levels and DISC : (i) expression of an H2A allele that can not be monoubiquitylated at lysine 119 partially rescues transcription (XREF_FIG), (ii) inhibition of the known H2A E3 ubiquitin ligase RNF8 and the related RNF168 partially reverses silencing (XREF_FIG), and (iii) depletion of the uH2A deubiquitylating enzyme USP16 prevents the reversal of silencing and diminution of uH2A at DSBs upon ATMi or cessation of damage."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...