IndraLab

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"Another, the expression of eIF3f is downregulated in many human tumors, the overexpression of eIF3f inhibits cell proliferation, and induces apoptosis in tumor cells ( Doldan et al., 2008; Shi et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that ectopic expression of constitutively active Akt partially rescued the obstructed proliferation caused by eIF3f knockdown."
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"Overexpressing eIF3f inhibits cell proliferation and induces apoptosis."
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"Recent reports on the biological function of eIF3f in translation and apoptosis in tumor cells demonstrated that eIF3f is down regulated in most human tumors and that overexpression of eIF3f inhibited cell proliferation suggesting a function associated with differentiation XREF_BIBR."
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"Conversely, eIF3f expression is a tumor suppressor in several cancers, including melanoma and pancreatic cancer, and overexpress eIF3f inhibits cell proliferation and induces apoptosis[ 29 ]."
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"EIF3F overexpression induces apoptosis in pancreatic and melanoma cancer cells and disrupts the proliferation of tumor cells (32,34,35)."
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"MD 11 -NF, MD 11 -wt eIF3f, and MD 11 -K510R induced inhibition of cellular proliferation in all target cell lines in a dose- and a time dependent manner."
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"Overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR Advances in the understanding of the molecular mechanism behind cellular carcinogenesis have shown that ectopic expression of eIF3f by transient gene transfection inhibits translation, cellular growth and proliferation and induces apoptosis."
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"In our current study, we found evidence that stable knockdown of eIF3f in normal human pancreatic ductal epithelial cells increased cell size, nuclear pleomorphism, cytokinesis defects, cell proliferation, clonogenicity, apoptotic resistance, migration, and formation of 3-dimensional irregular masses."
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"Conversely, eIF3f expression is suppressed in several cancers, including breast cancer. xref Overexpression of eIF3f inhibits cell proliferation, induces apoptosis, and inhibits translation and protein expression. xref eIF3e binds both to eIF4G and to 40S, thus generating an interaction between the eIF4F complex and the ribosome. xref Several studies support a tumor suppressor role for eIF3e."
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"Moreover , overproduction of eIF3F inhibits cap-dependent translation [ 32 ] ( also see Fig. 5 ) , and knockdown of eIF3F increases cell proliferation [ 46 ] ."
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"Haplotype analyses support a single mutational event on a founder haplotype, while the nascence of the missense variant cannot be determined to a more localized region.As only the identical missense variant in EIF3F has been functionally characterized and shown to result in reduced protein amount/ stability, decreased proliferation rate and reduced translational rate, it remains speculative whether other missense variants might have comparable effects."
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"We also showed that restored eIF3f expression in tumor cells causes ribosomal RNA (rRNA) degradation, inhibits translation and cell proliferation, and induces apoptosis XREF_BIBR."
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"Stable knockdown of eIF3f in the HPDE cells increased cell proliferation, clonogenicity, apoptotic resistance, survival, resistance to a chemotherapy drug (gemcitabine), mesenchymal morphology, and migration (XREF_FIG, XREF_SUPPLEMENTARY -D)."
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"Ectopic expression of eIF3e and eIF3f subunits in stably transfected NIH3T3 fibroblasts also inhibits cell growth and proliferation [XREF_BIBR]."
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"Ectopic overexpression of each eIF3 subunit (with the exception of eIF3m) in NIH 3T3 cells revealed that subunits eIF3a, eIF3b, eIF3c, eIF3h, and eIF3i stimulated global protein synthesis, accelerated[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recent reports on the biological function of eIF3f in translation and apoptosis in tumor cells demonstrated that eIF3f is down regulated in most human tumors and that overexpression of eIF3f inhibited cell proliferation suggesting a function associated with differentiation xref ."
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"18, 28 In this study, we demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that down-regulation of eIF3f is involved in tumorigenesis for many types of cancer."
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"XREF_BIBR Overexpression of eIF3f inhibits cell proliferation, induces apoptosis, and inhibits translation and protein expression."
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"It is demonstrated that the enforced expression of eIF3f inhibits translation, cell growth, cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, while knockdown of eIF3f i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, eIF3f reduced cancer cell proliferation significantly."
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"Previous studies have demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that downregulation of eIF3f is involved in tumorigenesis for many types of cancer [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"EIF3f is down-regulated in many human tumours, and over-expression of eIF3f inhibits cell proliferation and induces apoptosis in tumour cells (Shi etal., 2006; 2008a, 2008b)."
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