IndraLab

Statements

reach
"Recent reports on the biological function of eIF3f in translation and apoptosis in tumor cells demonstrated that eIF3f is down regulated in most human tumors and that overexpression of eIF3f inhibited cell proliferation suggesting a function associated with differentiation XREF_BIBR."
20126553
reach
"EIF3f is down-regulated in many human tumours, and over-expression of eIF3f inhibits cell proliferation and induces apoptosis in tumour cells (Shi etal., 2006; 2008a, 2008b)."
20444226
eidos
"Moreover , overproduction of eIF3F inhibits cap-dependent translation [ 32 ] ( also see Fig. 5 ) , and knockdown of eIF3F increases cell proliferation [ 46 ] ."
32030451
reach
"Previous studies have demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that downregulation of eIF3f is involved in tumorigenesis for many types of cancer [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
24678890
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR Advances in the understanding of the molecular mechanism behind cellular carcinogenesis have shown that ectopic expression of eIF3f by transient gene transfection inhibits translation, cellular growth and proliferation and induces apoptosis."
26052528
reach
"MD 11 -NF, MD 11 -wt eIF3f, and MD 11 -K510R induced inhibition of cellular proliferation in all target cell lines in a dose- and a time dependent manner."
26052528
reach
"Ectopic expression of eIF3e and eIF3f subunits in stably transfected NIH3T3 fibroblasts also inhibits cell growth and proliferation [XREF_BIBR]."
23354061
reach
"EIF3f is down-regulated in many human tumours, and over-expression of eIF3f inhibits cell proliferation and induces apoptosis in tumour cells (Shi et al., 2006; Doldan et al., 2008a,b) ."
20444226
reach
"In our current study, we found evidence that stable knockdown of eIF3f in normal human pancreatic ductal epithelial cells increased cell size, nuclear pleomorphism, cytokinesis defects, cell proliferation, clonogenicity, apoptotic resistance, migration, and formation of 3-dimensional irregular masses."
22457825
reach
"We found that ectopic expression of constitutively active Akt partially rescued the obstructed proliferation caused by eIF3f knockdown."
32440143
reach
"Overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells."
16532022
reach
"Haplotype analyses support a single mutational event on a founder haplotype, while the nascence of the missense variant cannot be determined to a more localized region.As only the identical missense variant in EIF3F has been functionally characterized and shown to result in reduced protein amount/ stability, decreased proliferation rate and reduced translational rate, it remains speculative whether other missense variants might have comparable effects."
33736665
reach
"We also showed that restored eIF3f expression in tumor cells causes ribosomal RNA (rRNA) degradation, inhibits translation and cell proliferation, and induces apoptosis XREF_BIBR."
22457825
sparser
"Conversely, eIF3f expression is suppressed in several cancers, including breast cancer. xref Overexpression of eIF3f inhibits cell proliferation, induces apoptosis, and inhibits translation and protein expression. xref eIF3e binds both to eIF4G and to 40S, thus generating an interaction between the eIF4F complex and the ribosome. xref Several studies support a tumor suppressor role for eIF3e."
26779407
sparser
"Recent reports on the biological function of eIF3f in translation and apoptosis in tumor cells demonstrated that eIF3f is down regulated in most human tumors and that overexpression of eIF3f inhibited cell proliferation suggesting a function associated with differentiation xref ."
20126553
reach
"XREF_BIBR Overexpression of eIF3f inhibits cell proliferation, induces apoptosis, and inhibits translation and protein expression."
26779407
reach
"Previous studies have demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that downregulation of eIF3f is involved in tumorigenesis for many types of cancer [11, 16, 19] ."
24678890
reach
"Stable knockdown of eIF3f in the HPDE cells increased cell proliferation, clonogenicity, apoptotic resistance, survival, resistance to a chemotherapy drug (gemcitabine), mesenchymal morphology, and migration (XREF_FIG, XREF_SUPPLEMENTARY -D)."
22457825
reach
"Therefore, eIF3f reduced cancer cell proliferation significantly."
26988917
reach
"18, 28 In this study, we demonstrated that overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, suggesting that down-regulation of eIF3f is involved in tumorigenesis for many types of cancer."
25684180