IndraLab

Statements

CASP8 inhibits CYLD. 13 / 17
| 10 3
reach
"We identified cFLIP upregulation that may promote caspase 8 mediated degradation of CYLD, and other necrosome components, as a possible mechanism abrogating Mtb 's capacity to coopt necroptotic signaling."
29229989
reach
"Neither RIPK1 nor RIPK3 was required for the processing of CYLD to CYLDp25 in MEFs (XREF_SUPPLEMENTARY), indicating that CASPASE 8 inactivation of CYLD occurs upstream of these necrosome components."
22037414
reach
"Neither RIPK1 nor RIPK3 were required for CYLD cleavage, and CYLD inactivation by casp8 is proposed to occur upstream of RIPK activity."
22889224
sparser
"Neither RIPK1 nor RIPK3 were required for CYLD cleavage, and CYLD inactivation by casp8 is proposed to occur upstream of RIPK activity."
22889224
reach
"In contrast, loss of CASPASE 8 prevented CYLD degradation resulting in necrotic death."
22037414
reach
"Caspase 8 then cleaves and inactivates RIPK1, RIPK3 and CYLD and stimulates apoptosis."
25015821
reach
"Caspase-8 inhibits the initiation of necroptosis by cleaving and inactivating RIP1, RIP3 [XREF_BIBR] and deubiquitinase CYLD, which was shown to be required for necroptosis induction [XREF_BIBR]."
23503762
reach
"It has recently been shown that during embryogenesis and T-cell proliferation active pro apoptotic caspase-8 blocks necroptosis by processing CYLD XREF_BIBR, XREF_BIBR, which is consistent with our findings of cross regulation of death pathways by caspase-1 activity."
22797665
reach
"Co-transfection of HEK 293 cells revealed that over-expression of wild-type CASPASE 8, but not the catalytically inactive mutant CASPASE 8-C360S, causes degradation of CYLD protein (XREF_FIG)."
22037414
reach
"Active caspase-8 has been reported to inhibit necroptosis by cleaving RIPK1, RIPK3, and CYLD XREF_BIBR - XREF_BIBR."
26924060
reach
"The apoptotic caspase-8 typically blocks necroptosis by cleaving RIPK3, CYLD, and RIPK1 [62,63,64]."
35563804
sparser
"Neither RIPK1 nor RIPK3 was required for the processing of CYLD to CYLDp25 in MEFs ( xref ), indicating that CASPASE 8 inactivation of CYLD occurs upstream of these necrosome components."
22037414
sparser
"Since caspase 8 is not recruited to the membrane-anchored TNFR-1 complex where CYLD is supposed to exert its effect [ xref , xref ], caspase 8 should not be able to cleave and inhibit CYLD at this complex."
24098568