IndraLab

Statements

CSN2 activates COPS5. 3 / 3
| 3
reach
"In the presence of CRL4A, conformational changes in CSN2, CSN4, and CSN7 affect the CSN5-CSN6 dimer and activate CSN5."
39600336
reach
"Furthermore, CSN2 knockdown of over 99% and CSN5 knockdown of over 95% was achieved at the mRNA level relative to mock transfectants as measured by quantitative real-time PCR (QRT-PCR)."
19400951
reach
"Interaction of the complex with a NEDDylated CRL leads to a series of conformational change events in Csn2, Csn4 and Csn7, triggering rearrangements in the Csn5 and Csn6 dimer, resulting in Csn5 activation by priming the Csn5 JAMM and MPN + motif for deNEDDylation [XREF_BIBR, XREF_BIBR]."
33099217