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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CSN2 activates COPS5. 2 / 2

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"Interaction of the complex with a NEDDylated CRL leads to a series of conformational change events in Csn2, Csn4 and Csn7, triggering rearrangements in the Csn5 and Csn6 dimer, resulting in Csn5 activation by priming the Csn5 JAMM and MPN + motif for deNEDDylation [XREF_BIBR, XREF_BIBR]."

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"Furthermore, CSN2 knockdown of over 99% and CSN5 knockdown of over 95% was achieved at the mRNA level relative to mock transfectants as measured by quantitative real-time PCR (QRT-PCR)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...