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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP10 deubiquitinates TAFAZZIN. 2 / 2

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"In the context of HCC, USP10 promotes HCC cell proliferation and metastasis by deubiquitinating and stabilizing YAP and TAZ, the effector transcription factors of the Hippo signaling pathway, and SMAD4, the major signaling effector of TGFβ signaling [39,40,]."

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"USP10 depletion enhanced the polyubiquitination of YAP/TAZ, promoted their proteasomal degradation, and ultimately arrested the proliferation of hepatocellular carcinoma in vitro and in vivo [38]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...