IndraLab

Statements

Modified EGFR leads to the phosphorylation of STAT3. 4 / 4
| 4
reach
"Moreover, ectopic expression of wild type Egfr in cKO-MT cells was sufficient to elevate Stat3 phosphorylation and Aldh1a3 transcript levels (XREF_FIG)."
27197172
reach
"EGFR overexpression induces specifically sustained Stat3 phosphorylation and transcriptional activity."
22751114
reach
"Remarkably, EGFR overexpression, which is frequent in HNSCC cells, not only reduces the level of phosphorylated STAT1 upon the activation of SHP2 but also stimulates the phosphorylation of STAT3, hence promoting the survival, proliferation and dissemination of cancer cells (XREF_FIG)."
24501692
reach
"Taken together, these results demonstrate that overexpression of EGFR mediates specifically sustained Stat3 phosphorylation and transcriptional activity."
22751114