IndraLab

Statements

STAMBP activates MCRs. 5 / 5
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"The MC2R is specifically activated by ACTH, while the other MCRs can be activated by α-MSH as well as ACTH xref ."
28378841
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"Other ligands like ACTH can also stimulate MC1R while α-MSH can activate other MCRs."
25155575
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"Instead, we hypothesize that an in vitro interaction between MCRs and GPR139 resulted in transactivation of the phospholipase C pathway through ACTH, α-MSH, and β-MSH activation of MCRs."
29599718
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"Even though these hormones are derived from different regions of the precursor POMC, because they share a core binding sequence His-Phe-Arg-Trp (HFRW), which is required for binding and activation of the receptors, ACTH can activate all five MCRs, whereas α-MSH can activate all MCRs except MC2R ( xref )."
20089716
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"As the major endogenous agonist in CNS, α-MSH activates neural MCRs to induce a negative energy balance, consisting the catabolic arm of melanocortin system [ xref ]."
28433713