IndraLab

Statements

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"Results Depletion of USP13 Induces Apoptosis and Suppresses Autophagy Impaired ERAD pathway causes prolonged ER stress , which activates alternative signal pathways and promotes apoptosis ( Hetz , 2012 ; Hetz and Papa , 2018 ; Tabas and Ron , 2011 ) ."
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"USP13, FBXL14 and c-Myc can interact with each other; USP13 inhibits the degradation of c-Myc, hence inhibition of USP13 promotes the apoptosis of glioma stem cells."
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"In addition, terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling (TUNEL) assay demonstrated that expression of the mutant c-Myc diminished the increased apoptosis caused by USP13 disruption in GSC derived xenografts (not depicted)."
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"USP13 suppression induces apoptosis upon EGFR inhibition of mutant NSCLC cells USP13 downregulation or inhibition severely compromised the viability of PC9 and HCC827 cells when cotreated with afatinib ."
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"In conclusion, this study demonstrated that USP13 was downregulated in septic myocardial injury tissues, and USP13 overexpression increased Nrf2 levels and reduced apoptosis."
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"3.3 USP13 suppression induces apoptosis upon EGFR inhibition of mutant NSCLC cells."
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"We then showed that over-expressing USP13 markedly suppressed inflammatory response, oxidative stress and apoptosis in H-FLSs upon IL-1beta or TNF-alpha challenge, whereas USP13 knockdown exhibited detrimental effects."
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"Additionally, it is found that USP13 abrogates cell apoptosis by preventing excessive ubiquitin-proteasome degradation of Bcl-XL."
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"However, in the context of hypoxic or oxidative stresses, USP13 loss caused a substantial decrease of cell viability and a significant increase of cell apoptosis in both TOV-21G and SW-1573 tumor models."
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"USP13 depletion induced cell apoptosis in ccRCC cells (SI Appendix, Fig. S4 P and Q)."
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