IndraLab

Statements

eidos
"USP13 suppression induces apoptosis upon EGFR inhibition of mutant NSCLC cells USP13 downregulation or inhibition severely compromised the viability of PC9 and HCC827 cells when cotreated with afatinib ."
33210294
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"In addition, terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling (TUNEL) assay demonstrated that expression of the mutant c-Myc diminished the increased apoptosis caused by USP13 disruption in GSC derived xenografts (not depicted)."
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"In conclusion, this study demonstrated that USP13 was downregulated in septic myocardial injury tissues, and USP13 overexpression increased Nrf2 levels and reduced apoptosis."
36916102
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"We then showed that over-expressing USP13 markedly suppressed inflammatory response, oxidative stress and apoptosis in H-FLSs upon IL-1beta or TNF-alpha challenge, whereas USP13 knockdown exhibited detrimental effects."
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"3.3 USP13 suppression induces apoptosis upon EGFR inhibition of mutant NSCLC cells."
33210294
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"However, in the context of hypoxic or oxidative stresses, USP13 loss caused a substantial decrease of cell viability and a significant increase of cell apoptosis in both TOV-21G and SW-1573 tumor models."
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"Additionally, it is found that USP13 abrogates cell apoptosis by preventing excessive ubiquitin-proteasome degradation of Bcl-XL."
37452432
eidos
"Results Depletion of USP13 Induces Apoptosis and Suppresses Autophagy Impaired ERAD pathway causes prolonged ER stress , which activates alternative signal pathways and promotes apoptosis ( Hetz , 2012 ; Hetz and Papa , 2018 ; Tabas and Ron , 2011 ) ."
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