IndraLab

Statements

USP10 activates stability. 2 / 2
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"For example , USP7 regulates the stability of both p53 and Mdm2 and maintains p53 ubiquitination levels ; 120 USP2 mediates the stability of Mdm2 ; 121 USP10 modulates p53 localization and stability ; 122 OTUB1 abrogates p53 ubiquitination and activates p53.123 Interestingly , USP10 can stabilize both mutated and wild-type p53 , with a dual role in tumorigenesis ."
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"Accordingly , inactivation of USP10 reduced Sirt6 abundance and stability and diminished Sirt6-induced downstream signaling in cardiomyocytes ."
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