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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UNC119 activates USP1. 1 / 1

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"The observations that the translation of the USP1 mRNA driven by the unfolded RG4 (7dG modified) was insensitive to stabilizing ligands but much more responsive to hnRNP H/F loss compared to the USP1 RG4 WT suggest that the dynamic equilibrium between RG4s and linear G rich sequences in cellulo results in low binding of hnRNP H/F to RG4s but, when preventing RG4 from folding, hnRNP H/F strongly bind the G rich RNA to potentiate translation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...