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UNC119 activates USP1. 1 / 1

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"The observations that the translation of the USP1 mRNA driven by the unfolded RG4 (7dG modified) was insensitive to stabilizing ligands but much more responsive to hnRNP H/F loss compared to the USP1 RG4 WT suggest that the dynamic equilibrium between RG4s and linear G rich sequences in cellulo results in low binding of hnRNP H/F to RG4s but, when preventing RG4 from folding, hnRNP H/F strongly bind the G rich RNA to potentiate translation."

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IndraLab

Statements

UNC119 activates USP1. 1 / 1

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