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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 bound to its increases the amount of CDKN1A. 1 / 1

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"A possible mechanism behind the changes in SWI-SNF composition could be that phosphorylation of TMF-1 by Fer and/or PDGFRbeta promotes disruption of the TMF-1-containing repressive SWI and SNF complex; this may lead to release of Brg-1 followed by its binding to p53, which activates the transcription of CDKN1A, although interaction with the kinase inactive receptor may maintain a repressive SWI and SNF complex and inhibit p21 expression."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...