A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

TP53 bound to its increases the amount of CDKN1A. 1 / 1
| 1
reach
"A possible mechanism behind the changes in SWI-SNF composition could be that phosphorylation of TMF-1 by Fer and/or PDGFRbeta promotes disruption of the TMF-1-containing repressive SWI and SNF complex; this may lead to release of Brg-1 followed by its binding to p53, which activates the transcription of CDKN1A, although interaction with the kinase inactive receptor may maintain a repressive SWI and SNF complex and inhibit p21 expression."