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PSMD14 increases the amount of SNAI1. 6 / 6
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"The protein level of SNAIL was gradually increased by PSMD14 in a dose-dependent manner ( Fig. 2 A)."
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"Our results showed that PSMD14 could stabilize GRB2 and upregulate its expression, suggesting that PSMD14 might also increase Snail1 expression through GRB2."
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"Subsequently, we observed that PSMD14 overexpression could strikingly increase SNAIL protein level and extend its half-life ( Fig. 2 C)."
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"Conversely, knockdown of PSMD14 decreased SNAIL level and accelerated its degradation ( Fig. 2 D)."
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"As shown in Fig. 3 B, endogenous SNAIL protein level, but not the mRNA level was dramatically increased by the stable overexpression of PSMD14 in KYSE510 cells."
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"PSMD14 overexpression significantly lowered the expression of E-cadherin but elevated the expression of vimentin and Snail (Fig. 4B)."
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