IndraLab

"[XREF_BIBR] Evidence from in vitro studies suggests that PSA is activated by kH2, a protein that is encoded by the closely related gene, kallikrein 2 (KLK2)."

"The PSA protein is encoded by the kallikrein 3 ( KLK3 ) gene, and the expression of PSA is mediated by the androgen receptor in both healthy and cancerous prostate tissues.[ xref ]Evidence from in vitro studies suggests that PSA is activated by kH2, a protein that is encoded by the closely related gene, kallikrein 2 ( KLK2 ).[ xref ]PSA is also involved in the proteolytic breakdown of the extracellular matrix in PCa tumorigenesis, which contributes to tumor invasion and metastasis,[ xref ]and high serum PSA correlates with mutations in p53 and the overexpression of the B-cell lymphoma 2 protein, which inhibits apoptosis in tumor cells.[ xref ]These findings strongly suggest that PSA plays a role in the etiology of PCa."