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CACNA1E activates calcium(2+). 8 / 8
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"The same set of mAbs was used to define the role of KChIP3-dependent Ca -mediated modulation of I underlying gain of stellate cell firing in response to repetitive stimulation (Anderson et al., 2013), and to block Kv4- and Ca -dependent EPSP boosting induced by SNX-sensitive Cav2.3 R-type Ca channels in CA1 pyramidal neurons (Figure 3) (Wang et al., 2014)."
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"Moreover, NSCLC cell lines (including those derived from patients of East Asian ancestry and European ancestry) exhibited higher levels of [Ca 2+ ] i than normal lung epithelial cells, and knockdown o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CACNA1E increased current density and Ca 2 + entrance , whereas calcium channel blockers inhibited NSCLC cell proliferation ."
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"Cav2.3 coexpression increases Kv4.2 current density and surface localization in a KChIP- and Ca 2+ -dependent manner."
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"CACNA1E, which encodes a subunit of the Ca2.3 channel, can be mutated to cause developmental and epileptic encephalopathy by increasing R-type calcium currents (Helbig et al., 2018)."
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"CACNA1E was shown to mediate a significant fraction of R-type Ca 2+ currents, specifically within the hippocampus [XREF_BIBR]."
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"Knockdown of CACNA1E significantly suppressed [Ca 2+ ] cyto (F 340 /F 380 ratio) in the H1299 and Glc-82 cells ( Fig. 5 K, Supplementary Figure 1C, D)."
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"Interestingly, re-expression of WT CACNA1E substantially increased [Ca 2+ ] cyto ( Fig. 5 K), suggesting that this channel is functional in regulating calcium flux."
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