IndraLab

Statements

ATXN3 activates CASP3. 7 / 7
| 7
reach
"For ataxias SCA1, SCA2, SCA3, SCA6, SCA7, SCA17 and dentatorubral-pallidoluysian atrophy, expansion beyond 39, 33, 45, 20, 34, 41, and 35 repeats in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, and ATN1 genes, respectively, will cause disease."
35592702
reach
"There are also 6 types of spinocerebellar ataxias (SCA1, SCA2, SCA3, SCA6, SCA7, SCA17), which are caused by expansions in the genes ATXN1 , ATXN2 , ATXN3 , CACNA1A , ATXN7 and TBP , respectively."
30597161
reach
"Ataxin gene variants in ATXN1, ATXN2, ATXN3, and ATXN7 cause SCA1, SCA2, SCA3, and SCA7, respectively."
29168350
reach
"At least 6 autosomal dominant forms of spinocerebellar ataxia (SCA1, 2, 3, 6, 7, and 17) are caused by CAG repeat expansions, the most common of these being SCA3, or Machado-Joseph disease (MJD)."
34327290
reach
"XREF_BIBR SCA1, SCA2, Machado-Joseph or SCA3, SCA6, SCA7, SCA12, SCA17, and dentatorubral-pallidoluysian atrophy (DRPLA) are caused by (CAG) n repeat expansions in the ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, PPP2R2B, TBP, and ATN1 genes, respectively, and all lead to the expansion of a polyglutamine tract in the corresponding proteins."
24780882
reach
"Recent studies showed that polyglutamine-expanded huntingtin or ataxin-3 also induced caspase-3 activation and apoptotic neuronal death by releasing cytochrome- c and Smac from mitochondria ( [48,49] [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15964171
reach
"SCA1, SCA2, and SCA3 are caused by large abnormal CAG trinucleotide repeat expansions in ATXN1, ATXN2, and ATXN3 genes, respectively (Chung et al., 1993; Orr et al., 1993; Kawaguchi et al., 1994; Pulst et al., 1996)."
37397792