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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Methylated p16 ink4a promoter leads to the methylation of mutated TP53. 1 / 1

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"Increased concentrations of these markers - promoter hypermethylation of multiple genes, especially p16 ink4a promoter hypermethylation and p53 mutations - have been shown to occur in chronic smokers before there is clinical evidence of neoplasia [XREF_BIBR - XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...