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USP10 ubiquitinates SIRT6. 2 / 2
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"Lin et al. found that USP10 antagonizes the transcriptional activity of c‐Myc by deubiquitinating and stabilizing SIRT6, to inhibit cell growth and tumor formation in colon cancers (Lin et al., 2013)."
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"Mechanistically, we demonstrated that USP10 activation and interaction with Sirt6 in response to angiotensin II led to a marked increase in the ubiquitination of Sirt6 and resulted in Akt signaling downregulation and attenuation of cardiomyocyte hypertrophy."
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