IndraLab

Statements

TEA inhibits KCNQ2. 3 / 3
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"A further complication is that the TEA block of KCNQ2 and KCNQ2 +3 has a Hill slope close to unity."
11448722
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"Because 3 mM TEA should selectively block primarily the Kv7.2 homomers and Kv7.2/Kv7.3 heteromers and not Kv7.3 homomers (Wang et al., 1998, Hadley et al., 2000, Lerche et al., 2000, Hadley et al., 2003), these results indicate that inhibiting Kv7.2 contributes to the decreased slow AHP peak undershoot observed in the mutant DRG neurons."
24687876
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"First, in contrast to the well-known relative insensivity of M-current to TEA (Adams et al., 1982b), KCNQ2 was blocked by TEA with a K d of 160 +/-20 nM."
10958929