IndraLab

Statements

TP53 is methylated on K373. 11 / 11
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"In addition, G9a (also known as EHMT2) and GLP (also known as EHMT1), which share 80% sequence homology in their respective SET domains [ xref , xref ], have been found to methylate p53 at K373, correlating with inactivation of p53 [ xref ]."
21966347
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"P53 Methylation at K370, K373, and K382 suppresses p53 transcriptional activity, whereas methylation at K372 facilitates its activity."
33462212
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"In general, while methylation of p53 at K370, K373 and K382 represses p53 transcriptional activities, methylation at K372 enhances p53 activities. xref – xref Since KDM3A knockdown activated the expression of p53-dependent genes, we reasoned that increasing p53 methylation enhanced its transcriptional activities."
27270439
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"Two KMTases, G9a and Glp, responsible for K373 methylation of p53, also catalyse mono and di-methylation of H3K9 and mono-methylation of H3K27 [ xref ]."
24298606
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"Much like methylation of K373 in p53, G9a-mediated methylation of H3K9 leads to transcriptional repression [ xref ]."
24298606
sparser
"However, is still unclear whether this cellular effect is a direct result of p53 K373 methylation, or whether it is caused by repressive methylation of histones in the promoters of pro-apoptotic target genes."
24298606
sparser
"Genetic knockdown of G9a inhibits cancer cell growth and the di-methylation of p53 K373 results in the inactivation of p53."
20614940
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"G9a is indeed responsible for p53 methylation at lysine 373, and this form of the transcription factor was observed to be inactive ( xref )."
26441991
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"It has been shown that in the absence of exogenous stimulation, spontaneous/endogenous stress can induce deacetylation and methylation at K373 and K382 of p53, and this suppresses the transcriptional activity of p53, and the resulting p21 gene expression."
28208785
sparser
"P53 methylation at K370, K372, K373, and K382 by the PKMTs SETD7 xref , SMYD2 xref and SETD8 xref , SETDB1 xref , GLP/G9A xref suppresses p53 transcriptional activity in several cancer cell line models, including lung, kidney, and bone."
30683849
sparser
"G9a was also reported to methylate p53 at Lys373, which is associated with p53 activity [ xref ]."
28787001