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RPS6KB1 phosphorylates RPS6. 394 / 410
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"However, we demonstrated that while both rapamycin treatment and chemical inhibition of p70S6K with FRI00705 effectively suppressed S6 and rictor phosphorylation, p-Akt levels were potently elevated b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results demonstrate that, in imatinib resistant KCL22 cells, inhibition of either CK2 or p70S6K almost abolishes rpS6 phosphorylation, while the inhibition of one kinase does not influence the activity of the other."
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"In LN229 and GAMG glioblastoma cells treated with either non targeting or PTEN targeting siRNA (siNT and siPTEN, respectively), both AD80 and LY-2779964 (LY64) were effective in reducing the S6K1 dependent phosphorylation of the ribosomal protein S6 (rpS6) at 3 hours (XREF_FIG, XREF_SUPPLEMENTARY)."
sparser
"Additionally, the mGluR1/5-stimulated ERK1/2 activation may impinge on S6K1 (p70-S6 kinase 1), which phosphorylates ribosomal protein S6 and contributes to the enhancement of 5′TOP (terminal 5′ oligopyrimidine tract) mRNA translation ( xref )."
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"These results suggest that the hyper-phosphorylation of rpS6 is not directly mediated by an increased activation of its kinases RSK and p70S6K."
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"mTORC1 activated p70S6K phosphorylates the 40S-ribosomal protein S6."
sparser
"In response to mitogen stimulation, mTOR phosphorylates and activates S6K1, which in turn phosphorylates the 40S ribosomal protein S6, leading to the enhancement of translation of mRNAs with a 5′-terminal oligopyrimidine, including mRNAs that encode for ribosomal proteins and elongation factor-1."
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"mTOR activation has been linked to cardiac hypertrophy by phosphorylating downstream targets including eukaryotic initiation factor 4E binding protein 1 (4E-BP1) and ribosomal S6 kinase (p70S6K), which leads to increased phosphorylation of ribosomal protein S6 (S6)."
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"Since p70S6K can also phosphorylate rpS6, the actual effect of the RSK inhibitors on rpS6 phosphorylation could be masked."
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"S6K1 phosphorylates eIF-4B and S6 ribosomal protein (S6RP), initiating translation."
sparser
"S6K1 directly phosphorylates the 40S ribosomal protein S6, and then promotes ribosome biogenesis."
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"S6 is phosphorylated at Ser235/236 by p70S6 kinase."
sparser
"FRAP may activate p70 S6 kinase which phosphorylates the S6 subunit of the 40S ribosomal subunit, an event that correlates with growth factor-regulated increases of translation of defined, growth regu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
sparser
"In turn, p70S6K1 phosphorylates a S6 protein of the 40S ribosomal subunit (S6rp) and 4E-BP1, with the latter negatively regulating eukaryotic initiation factor 4E (eIF-4E)."
sparser
"Its major effects are mediated by phosphorylation of proteins involved in the regulation of protein synthesis such as 4EBP1 and p70S6K, with subsequent phosphorylation of ribosomal S6 protein by p70S6K, and the components of ULK1 kinase that play a critical role in the regulation of autophagy [ xref ]."
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"mTORC1 consists of mTOR, mLST8, Raptor, Deptor, and PRAS40 and phosphorylates the elF4E binding protein (4F-BP) and p70 S6 kinase 1 (S6K1), a serine/threonine kinase that phosphorylates the ribosomal protein S6."
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"In order to evaluate the possible targeting of the mTOR pathway by both MTH (through raptor) and RAPA (through mTOR binding by FKBP12), we compared the effects of these two inducers on the phosphorylation of p70S6Kinase (p70S6K), which specifically phosphorylates the ribosomal protein S6, strongly involved in sustaining protein synthesis and cell growth [XREF_BIBR, XREF_BIBR]."
sparser
"The kinase p70S6K phosphorylates the S6 protein on the 40S ribosomal subunit allowing mRNA translation xref ."
sparser
"Activated mTORC1 phosphorylates S6K1, which phosphorylates S6 (40S ribosomal protein S6), enhancing the translation of mRNAs with a 5′-terminal oligopolypyrimidine (5′-TOP)."
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"One target of mTOR is the ribosomal S6 kinase (S6K1) that phosphorylates the ribosomal protein S6 XREF_BIBR."
sparser
"On the other hand, activated p70S6K1 phosphorylates the ribosomal protein S6 and eukaryotic elongation factor 2 kinase (eEF2K) leading to increased translational efficiency."
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"Once phosphorylated, 4E-BP1 dissociates from eIF4E whereas p70S6K phosphorylates ribosomal protein S6, thus promoting mRNA translation [XREF_BIBR]."
sparser
"The p70 S6 kinase-mediated phosphorylation of rictor (Thr1135) has been reported to be ( xref ) or not to be ( xref ) a negative regulator of mTORC2-mediated phosphorylation of Akt(Ser473)."
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"P70 S6 kinase 1 (S6K1), another downstream effector of mTORC1, phosphorylates ribosomal protein S6, which also is associated with increased translation."
sparser
"The activated p70s6k then phosphorylates 40S ribosomal protein S6, leading to an increased rate of translation of the class of 5′TOP mRNA transcripts."
sparser
"While p70S6K phosphorylates ribosomal S6 protein potentially modulating its activity, 4EBP1 binds and inactivates a factor of initiation of Cap-dependent transcription eIF4E. In its hypophosphorylated forms, 4EBP1 has high avidity to eIF4E causing inhibition of translation of many mRNA with structured 5′UTR, encoding proteins critical for cell growth and metabolism."
sparser
"Active p70S6K phosphorylates the ribosomal protein S6, enhancing translation of mRNA transcripts involved in cell cycle progression ( xref )."
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"S6K1 phosphorylates S6, which leads to enhanced translation initiation of the 5 ' terminal oligopyrimidine tract containing mRNAs encoding components of the protein synthesis machinery (ribosomal prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Phosphorylation of ribosomal protein S6, which is mediated by an mTORC1 target p70 S6 kinase (S6K), is dramatically increased in tumors isolated from Sesn2 -/- mice (XREF_FIG and XREF_FIG)."
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"Phosphorylation of S6 by S6K1 mediates unwinding and initiates translation of 5 terminal oligopyrimidine tract (TOP) mRNAs."
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"mTOR is activated by AKT and it stimulates protein translation by phosphorylating eIF4E binding protein (4E-BP1) as well as p70S6K which phosphorylates S6."
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"During the activation of mTORC1, its substrate p70S6K phosphorylates ribosomal protein S6 [XREF_BIBR]."
biopax:netpath
No evidence text available
sparser
"P70S6K phosphorylates and activates S6, a ribosomal subunit involved in initiating translation of 5′ terminal oligopyrimidine tract-containing mRNA encoding components of the protein synthesis machinery."
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"On activation, PI3-K phosphorylates inositol lipids that act as second messengers to activate different downstream effector kinases such as the PKB and AKT kinase, which is involved in cell survival, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
sparser
"S6K1 phosphorylates the ribosomal protein S6 (RPS6) thereby connecting the TOR pathway with ribosomes."
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"Although both RSK2 and S6K1 phosphorylate S6 in vivo, these kinases do not appear to be functionally redundant for a few reasons."
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"Phosphorylation of ribosomal protein S6 by p70 S6 kinase, which is believed to be involved in regulating 5 '-TOP mRNA translation [XREF_BIBR], is one of the earliest events detected following mitogenic stimuli, as part of liver regeneration of following fasting and refeeding."
sparser
"Conversely, TORC1 activation drives protein synthesis via phosphorylation of S6K1, which phosphorylates the ribosomal protein S6 and initiates the translation of messenger RNA."
sparser
"Upon activation, S6K1 phosphorylates ribosomal protein S6 (RPS6) to stimulate ribosomal biogenesis [ xref ], eukaryotic elongation factor 2 kinase (eEF2K) to de-repress translational elongation [ xref ], as well as eIF4B to heighten translational initiation [ xref , xref ]."
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"Similarly, an inhibitor of p70 S6 kinase (PF-4708671) partially inhibited phosphorylation of S6 and preserved RP, while only marginally prevented cyclin D1 induction."
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"The 70-kD ribosomal protein S6 kinase (p70S6K), which directly phosphorylates ribosomal protein S6, is a key effector of mTOR."
sparser
"Phosphorylation of S6 by S6K1 mediates unwinding and initiates translation of 5 terminal oligopyrimidine tract (TOP) mRNAs."
sparser
"S6K1, an evolutionarily conserved nutrient-sensing enzyme, phosphorylates the 40S ribosomal protein S6 to regulate the translation of 5′-terminal oligopyrimidine tract (5′TOP) -containing mRNA transcripts and is a downstream target of mTOR ( xref )."
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"One such substrate is p70S6 kinase, which phosphorylates ribosomal protein S6 as well as several other proteins XREF_BIBR."
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"S6K1 phosphorylates the S6 ribosome, thus stimulating protein synthesis."
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"The cellular effects of mTOR are largely mediated by its activation of the p70S6 kinase, which itself phosphorylates ribosomal protein S6 (S6)."
sparser
"One such substrate is p70S6 kinase, which phosphorylates ribosomal protein S6 as well as several other proteins xref ."
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"The S6 ribosomal protein is phosphorylated by p70 S6 kinase (p70S6k)."
sparser
"To determine the relative activity of S6K1 downstream of BCR-ABL under nutrient limiting conditions, we examined S6K1 phosphorylation and the phosphorylation of the ribosomal protein S6 over time after switching cells to low glucose conditions."
sparser
"It has been demonstrated that the activation of the PI3K/Akt/mTOR signaling pathway increases the phosphorylation of p70S6K and 4EBP1, and that p-p70S6K subsequently induces the phosphorylation of the ribosomal protein S6."
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"Similarly, changes in muscular mTOR pathway signaling were probed by measuring insulin induced phosphorylation of S6 kinase 1 (S6K1)."
sparser
"mTORC1 activates p70S6K, which in turn phosphorylates the ribosomal protein S6 and 4E-BP1, both involved in protein translation."
sparser
"P70S6K subsequently phosphorylates the ribosomal S6 subunit (S6) [ 20 , 23–26 ]."
sparser
"The p70S6K protein phosphorylates the 40S ribosomal protein S6 and the translation initiation factor eIF4B. The pivotal role of mTOR pathway in the generation of cardiac hypertrophy is underscored by the studies which show that rapamycin, an inhibitor for mTOR, attenuates the development of cardiac hypertrophy induced by aortic constriction. xref Our data show that the mTOR pathway is upregulated in the hypertrophic heart, which is attenuated in the cathepsin K knockout mice."
rlimsp
"The serine/threonine kinase p70 S6 kinase (p70S6K) phosphorylates the 40 S ribosomal protein S6, modulating the translation of an mRNA subset that encodes ribosomal proteins and translation elongation factors."
sparser
"S6Ks phosphorylate ribosomal protein S6 (rpS6) and additional proteins involved in the translational machinery, although the functional roles of these modifications remain elusive."
sparser
"Detection of LPS by TLR4 activates PI3K through the recruitment of the MyD88 and TRIF adaptors, leading to AKT and mTOR activation and finally ending by S6 protein phosphorylation by S6K1."
sparser
"Phosphorylated p70S6K further phosphorylates the 40S ribosomal protein S6, leading to enhancement of the translation of mRNAs."
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"Furthermore mTORC1 phosphorylates and activates p70S6 kinase (p70S6K) which in turn phosphorylates the ribosomal protein S6 (RPS6), a component of the 40S ribosomal protein which regulates the initiation of protein translation."
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"Well characterized effector targets of mTORC1 includes 4E-BP1 (4E binding protein), ribosomal protein S6 kinase and S6K1 (p70S6 kinase) which, in turn, phosphorylates the ribosomal protein S6 (S6/RPS6)."
sparser
"Prime candidate targets include: eIF4E, the cap-binding initiation factor, in which the phosphorylation site is now recognized to be serine209 [57]; ribosomal protein S6, which is phosphorylated by bo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"S6, a component of the 40S ribosomal subunit, is phosphorylated by S6K1, which under growth promoting conditions causes increased rates of protein synthesis."
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"Although S6 ribosomal protein (S6) is phosphorylated by p70S6 kinase and therefore lies downstream of mTOR, previous studies have not found a correlation between S6 phosphorylation and either PTEN levels or PKB and Akt phosphorylation in primary GBM specimens [XREF_BIBR], likely reflecting the importance of other pathways in controlling mTOR activity in these tumors."
sparser
"mTOR, structurally related to PI3K, is involved in the regulation of p70S6K, which in turn phosphorylates the S6 protein of the 40S ribosomal subunit."
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"Rapamycin strongly inhibits S6K1 phosphorylation of S6 but also has a minor effect on Akt phosphorylation."
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"It has been observed that there may be a relationship between the phosphorylation of ribosomal protein S6 (RPS6) by p70 ribosomal protein S6 kinase 1 and translational activation of TOP mRNAs XREF_BIBR."
sparser
"P70S6 kinase phosphorylates ribosomal protein S6, and possibly the initiation factors eIF4B and eIF4G."
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"The PI3K and mTOR signaling pathway controls phosphorylation of 4E-BP1 and S6K, and S6K1 also phosphorylates S6, and has been proposed to phosphorylate EF2K and pdcd4, controlling the activity of S6 and EF2K, and protein stability of pdcd4 [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
sparser
"While S6 is predominantly phosphorylated by p70S6K in most mammalian adult tissues, phosphorylation of S6 by p90rsk is important during meiosis in mammalian and amphibian oocytes [ xref , xref ], and to a lesser extent in growth factor stimulated hepatocytes [ xref ]."
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"These results show that haloperidol promotes mTORC1- and S6K1 dependent phosphorylation of rpS6 at Ser240/244, in a subpopulation of striatal MSNs expressing D2Rs."
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"Among the best characterized mTOR substrates are S6K1, which phosphorylates the ribosomal protein S6 and regulates the translation process [XREF_BIBR], and eIF4E-BP1, which is involved in the formation of an active translation initiation complex [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"P70S6K phosphorylates ribosomal protein S6 (S6) to promote protein synthesis."
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"Once activated, S6K1 phosphorylates rpS6 and eIF4B (reviewed in Fingar and Blenis, 2004)."
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"mTORC1 phosphorylates proteins involved in protein synthesis and cell growth, including 4E-BP1 and p70S6 kinase 1 (S6K1), which phosphorylates the ribosomal protein S6."
sparser
"mTOR is activated by AKT and it stimulates protein translation by phosphorylating eIF4E binding protein (4E-BP1) as well as p70S6K which phosphorylates S6."
sparser
"The mTORC1 controls the rate of protein synthesis through phosphorylation and activation of its substrates, p70S6 ribosomal kinase 1 (p70S6K) and eukaryotic translation initiation factor 4E (eIF4E) binding protein-1 (4E-BP1) and once phosphorylated, p70S6K phosphorylates ribosomal protein S6 and 4E-BP1 becomes dissociated from eIF4 and promote mRNA translation and protein synthesis [ xref ]."
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"Activation of p70S6K by mTORC1 via phosphorylation at threonine 389 promotes phosphorylation and activation of ribosomal protein S6 (rpS6) and eukaryotic initiation factor 4B (eIF4B)."
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"S6K1, a key regulator of cell growth, phosphorylates ribosomal protein S6 and enhances the translation of 5 '-terminal oligopyrimidine tract mRNAs in some models."
sparser
"mTOR activates S6K1, which phosphorylates eIF4B and S6, so promoting translation initiation, and this may be enhanced by ASF/SF2 xref ."
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"Indeed, the exogenous leucine was able to restore TCR and CD28 stimulated phosphorylation of S6 and its kinase S6K1 (XREF_SUPPLEMENTARY)."
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"Activated mTOR phosphorylates the eukaryotic initiation factor 4E binding protein 1 (4E-BP1) and the p70 ribosomal S6 kinase 1 (S6K1), which phosphorylates the ribosomal protein S6 and consequently regulates protein synthesis."
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"Phosphorylated 4EBP1 allows active eIF4E.eIF4G complex formation and activated S6K1 phosphorylates ribosomal protein S6."
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"The serine/threonine kinase p70 S6 kinase (p70S6K) phosphorylates the 40 S ribosomal protein S6, modulating the translation of an mRNA subset that encodes ribosomal proteins and translation elongation factors."
sparser
"S6K1 and S6K2 phosphorylate and activate the 40S ribosomal protein S6, which promotes protein synthesis through an increased rate of mRNA transcription. xref S6K1 also regulates cell size and progression through the cell cycle, xref − xref in addition to promoting cell survival by inactivating the proapoptotic protein BAD. xref "
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"In parallel, FSH induced p70S6K activity triggers a robust phosphorylation of rpS6."
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"AKT1S1 (PRAS40) contains a consensus phosphorylation motif and is a direct substrate for AKT, a mediator of PI3K signaling [XREF_BIBR], while RPS6 is phosphorylated at Ser235/236 by p70S6 kinase."
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"After engagement of TCR and CD28, p70S6K becomes activated and phosphorylates S6, which leads to increased ribosome biogenesis."
sparser
"S6K1 phosphorylates S6, which leads to enhanced translation initiation of the 5′ terminal oligopyrimidine tract-containing mRNAs encoding components of the protein synthesis machinery (ribosomal prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"One clue, involving translational control, is the activation of p70 S6 kinase, which phosphorylates the ribosomal S6 protein (Shioi et al., 2002)."
sparser
"The p70-S6K1 protein is activated by mTOR and subsequently phosphorylates the ribosomal S6 protein (RPS6), eukaryotic transcription initiation factor 4B (EIF4B), and eukaryotic elongation factor 2-kinase (eEF2 k) and is a positive regulator of protein translation (reviewed in [ xref ])."
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"mTOR activates S6K1, which phosphorylates eIF4B and S6, so promoting translation initiation, and this may be enhanced by ASF and SF2 XREF_BIBR."
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"In addition, we examined two phosphorylation sites on rpS6, Ser240/244, that are uniquely phosphorylated by S6K1 and S6K2."
sparser
"S6 phosphorylation by S6K1 is involved in a plethora of biologic processes including cell proliferation, translation initiation, and metabolic regulation and is known to be activated downstream of the PI3K-mTOR axis ( xref – xref ); very little has been studied regarding the specific involvement of S6K1 in drug resistance."
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"In turn, S6K1 phosphorylates and activates S6, a ribosomal protein involved in protein translation."
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"Activation of mTOR results in phosphorylation and activation of the 70-kDa ribosomal protein S6 kinase 1 (S6K1) which, in turn, phosphorylates ribosomal protein S6 (S6)."
sparser
"P70S6K kinase directly phosphorylates the 40S ribosomal protein S6, which results in enhanced translation of proteins that contain a polypyrimidine tract in the 5′-untranslated region [ xref ]."
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"Since LKB1 is a regulator of mTOR activity through the phosphorylation of the energy sensor AMPK, in the absence of this regulation, mTOR is active whereby it phosphorylates S6K1, that in turn phosphorylates pS6, ultimately leading to protein translation XREF_BIBR."
sparser
"Once activated, S6K1 phosphorylates rpS6 and eIF4B (reviewed in Fingar and Blenis, 2004 )."
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"Based on our data pointing to critical involvement of mTOR signaling in TTL short / high-risk leukemia, we addressed mTOR pathway activity by investigating phosphorylation of key signaling molecules : ribosomal protein S6 (S6), a downstream molecule which is phosphorylated by the ribosomal protein S6 kinase (p70S6K1) upon mTOR activation; and AKT, an upstream signaling kinase that is activated by phosphatidylinositol 3-kinase (PI3K) also mediating mTOR activation."
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"RPS6KB1 phosphorylates specifically ribosomal protein S6."
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"P70S6K phosphorylates ribosomal protein S6 and regulates protein translation [11]."
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"S6 is phosphorylated by ribosomal protein p70 S6 kinase (S6K), which is activated by mTORC1."
sparser
"In turn S6K1 phosphorylates and activates S6 ."
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"In response to mitogenic stimuli, p70S6K phosphorylates S6 on multiple sites, and it is believed that these modifications favor the recruitment of the 40S subunit into actively translating polysomes [[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"mTORC1 phosphorylates and activates p70S6K which in turn phosphorylates ribosomal protein S6 to enhance translation efficiency XREF_BIBR."
sparser
"P70S6K phosphorylates ribosomal protein S6 and regulates protein translation [11] ."
sparser
"To determine if mTORC1 activity is enhanced in GSK3-deficient B cells, we measured the abundance of mTORC1-phosphorylated p70S6K (T389), as well as p70S6K-phosphorylated ribosomal protein S6 (S235, S236, S240 and S244) in anti-CD40+IL-4–stimulated B cells ( xref )."
sparser
"In this murine HF model, the downstream mTOR signaling proteins S6K1 and S6 were both increased in TAC-HF, although the abundance of Thr389 phosphorylated S6K1 and Ser235/236 phosphorylated S6 were not increased in HF ( xref )."
sparser
"P70S6K kinase directly phosphorylates the 40S ribosomal protein S6, which results in enhanced translation of proteins that contain a polypyrimidine tract in the 5’-untranslated region [ xref ]."
sparser
"mTORC1 controls mRNA translation, in part, by phosphorylating and activating S6K1 which phosphorylates the S6 protein of the 40S ribosomal protein ( xref )."
sparser
"mTORC1-activated p70S6K phosphorylates the 40S-ribosomal protein S6 ( xref )."
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"Active S6K1 can stimulate the protein synthesis by phosphorylating S6 ribosomal proteins."
sparser
"P70S6K is activated by mTORC1 and phosphorylates S6."
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"Activated mTOR phosphorylates p70 S6 kinase, followed by activated p70 S6 kinase that phosphorylates ribosomal protein S6, and as a result, increases the protein synthesis complex."
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"Additionally, the mGluR1/5 stimulated ERK1/2 activation may impinge on S6K1 (p70-S6 kinase 1), which phosphorylates ribosomal protein S6 and contributes to the enhancement of 5 ' TOP (terminal 5 ' oligopyrimidine tract) mRNA translation."
sparser
"S6Ks, which phosphorylates ribosomal S6 protein, are effectors of the mTOR pathway."
| PMC
sparser
"In mammals, the TORC1 controlled S6K1 kinase phosphorylates the ribosomal protein S6 thereby co-ordinating cell size and nutritional status."
sparser
"P70S6 kinase phosphorylates the ribosomal protein S6 with subsequent enhancement of translation of mRNAs bearing a 5′-terminal oligopyrimidine tract."
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"It is a serine/threonine kinase, which phosphorylates at least three downstream substrates : the translation repressor eIF4E binding protein (4E-BP) (von Manteuffel et al, 1997; Gingras et al, 1999; Nojima et al, 2003); p70S6K, which phosphorylates ribosome protein S6 (Nojima et al, 2003); and signal transducer and activator of transcription 3 (Stat3) (Yokogami et al, 2000; Kusaba et al, 2004)."
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"While p70S6K can phosphorylate RPS6 at all sites, S235/236 is a specific target for RSK [XREF_BIBR]."
sparser
"However, rpS6 can also be phosphorylated by S6K1 on both its Ser235/236 and Ser240/244 regulatory sites [ xref ]."
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"mTOR signaling leads to the activation of p70S6 kinase, which phosphorylates S6 ribosomal protein."
sparser
"P70S6K kinase directly phosphorylates the 40S ribosomal protein S6, which results in enhanced synthesis of proteins that contain a polypyrimidine tract in the 50-untranslated region ( xref )."
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"Since a key downstream target of PDK1 is p70S6K, which phosphorylates S6 [XREF_BIBR, XREF_BIBR], we hypothesized that if UCN-01 inhibited PDK1, we would observe reduced pS6."
sparser
"However, S6 phosphorylation by S6K1 is only minimally influenced by removal of the CTD, or by phospho-defective or -mimetic mutations ( xref ; xref ; xref )."
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"However, rpS6 can also be phosphorylated by S6K1 on both its Ser235/236 and Ser240/244 regulatory sites [XREF_BIBR]."
sparser
"Furthermore mTORC1 phosphorylates and activates p70S6 kinase (p70S6K) which in turn phosphorylates the ribosomal protein S6 (RPS6), a component of the 40S ribosomal protein which regulates the initiation of protein translation (see review [ xref ])."
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"S6 phosphorylation in mammalian cells is catalyzed by the protein kinase RPS6KB1, usually called p70 S6 [XREF_BIBR, XREF_BIBR], which in turn is activated by sequential phosphorylation by mTOR complex1 (most importantly at S6K1 (Thr389) and PDPK1 [XREF_BIBR, XREF_BIBR]."
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"Unstimulated COS cells contain active p70S6K, which phosphorylates ribosomal S6 protein as well as CREM in vitro."
sparser
"Regulation of protein synthesis via mTOR also occurs through its phosphorylation of p70S6K, which then phosphorylates the S6 40S ribosomal subunit."
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"Active mTORC1 in turn phosphorylates p70S6K, which then phosphorylates eukaryotic initiation factor 4B (eIF4B) and ribosomal protein S6 (RPS6), which are directly involved in the formation of the mRNA translation pre and initiation complex (XREF_FIG) XREF_BIBR."
sparser
"As mentioned, S6K1 phosphorylates S6, eIF4B, as well as eEF2 kinase, suggesting that S6K1 is involved with both the initiation and elongation phases of protein synthesis xref ."
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"However, recent data suggest that ribosomal S6 phosphorylation by S6K1 is not acting alone in this growth pathway as growth factors are able to stimulate translation of 5 ' TOP containing mRNAs even i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the present study, we have examined whether Ang II activates p70 S6 kinase (p70S6K), which has been reported to phosphorylate S6 protein."
sparser
"It was originally thought that the phosphorylation of S6 by S6K1 was responsible for the translation of TOP mRNAs."
sparser
"Activated mTORC1 phosphorylates downstream effector p70S6K1, which subsequently phosphorylates 40s ribosomal protein S6 (pS6), promoting protein translation and cell growth."
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"For translational regulation, a clue as to how Rac acts may lie in its reported ability to interact with p70S6K (Bishop and Hall, 2000), which phosphorylates the ribosomal protein S6 and thereby promo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Phosphorylation of the ribosomal S6 protein by S6K1 regulates the translation of both ribosomal proteins and initiation factors, leading to an increase in protein synthesis."
sparser
"Small interfering RNA knockdown of the mTOR substrate p70 S6 kinase abrogated PAK1 phosphorylation and enhanced HCV RNA abundance, whereas overexpression of a constitutively active alternate substrate, eukaryotic translation initiation factor 4E-binding protein 1, increased cap-independent viral translation and viral RNA abundance without influencing PAK1 phosphorylation."
biopax:netpath
No evidence text available
sparser
"S6K1 phosphorylates ribosomal protein S6 (S6) and enhances the translation of mRNAs [ xref , xref ]."
sparser
"Activation of mTOR results in the phosphorylation and activation of S6K1, which in turn phosphorylates ribosomal protein S6, and finally stimulates translation initiation and protein synthesis."
sparser
"When activated, p70 S6 kinase phosphorylates the S6 protein of the 40S ribosome, and this has been suggested to allow preferential translation of a family of mRNAs with 5′ polypyrimidine tracts [86, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
sparser
"Once activated, S6K1 phosphorylates S6 ( xref )."
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"S6K is represented by two homologous cellular proteins, S6K1 and S6K2, both of which act downstream of mTOR and phosphorylate S6."
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"p70 S6 kinase 1 (S6K1), another downstream effector of mTORC1, phosphorylates ribosomal protein S6, which also is associated with increased translation."
sparser
"Rapamycin strongly inhibits S6K1 phosphorylation of S6 but also has a minor effect on Akt phosphorylation."
sparser
"P70s6k in turn phosphorylates rpS6 which is a ribosomal protein specific to anabolic protein synthesis in myotubes."
sparser
"Likewise, activated S6K1 phosphorylates ribosomal protein S6 that also participates in translation initiation ( xref )."
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"The serine/threonine kinase p70 S6 kinase (p70S6K) phosphorylates the 40 S ribosomal protein S6, modulating the translation of an mRNA subset that encodes ribosomal proteins and translation elongation factors."
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"Phosphorylation by mTORC1 at Thr389 activates p70S6K, which in turn phosphorylates ribosomal protein S6, and may influence translation of TOP RNAs."
sparser
"Akt activation can also induce stimulation of mTOR that will lead to phosphorylation of the 40S ribosomal S6 protein by the p70S6 kinase, thereby enabling efficient translation of 5′ terminal oligopyrimidine tract (5′TOP) mRNA [ xref ]."
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"A major downstream molecule of the mTOR axis is p70 S6 kinase, which, activated by mTOR, phosphorylates the S6 ribosomal protein to initiate protein synthesis."
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"Figure XREF_FIG shows the effects of AZD-8055 on the phosphorylation of Rps6, which is phosphorylated by the protein kinase Rps6kb1 (i.e., p70S6K), which is activated by mTOR."
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"It has been observed that there may be a relationship between the phosphorylation of ribosomal protein S6 (RPS6) by p70 ribosomal protein S6 kinase 1 and translational activation of TOP mRNAs XREF_BIBR."
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"Therefore, we might hypothesize that the phosphorylation of rpS6 by p70S6K is under the control of a CK2 mediated regulatory mechanism."
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"In addition, the p70S6K immunoprecipitated from nuclear extracts of unlabeled COS cells phosphorylates S6 protein in an in vitro immunokinase assay."
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"S6K1 in turn phosphorylates the ribosomal protein S6."
sparser
"S6K1 (p70S6 kinase) phosphorylates S6 which controls the translation of mRNA that possesses an unusual oligopyrimidine tract at its transcription starting site termed 5'TOP."
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"FRAP may activate p70 S6 kinase which phosphorylates the S6 subunit of the 40S ribosomal subunit, an event that correlates with growth factor regulated increases of translation of defined, growth regu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
sparser
"The C1 prototype is responsible for activating p70S6K, which in turn phosphorylates the ribosomal protein S6 and 4E-BP1 — which is inhibited by rapamycin (Corradetti et al., 2006;)."
reach
"To investigate mTOR pathway activity in acquired immunodeficiency syndrome (AIDS) related diffuse large B-cell lymphoma AR-DLBCL, we used immunohistochemistry to examine the presence of the phosphorylated 70 ribosomal S6 protein-kinase (p70S6K), an extensively studied effector of mTOR Complex 1 (mTORC1) and the phosphorylated phosphatase and tensin homolog (pPTEN), a negative regulator of mTORC1 pathway."
reach
"Among other things, mTOR activates the ribosomal protein S6 kinase 1 (S6K1), which phosphorylates the ribosomal S6 protein, leading to increased cell growth."
sparser
"Another important locus for regulation of mRNA binding to 40S ribosomal subunits occurs through phosphorylation of ribosomal protein S6 by S6K1."
reach
"S6K1 phosphorylates ribosomal protein S6 (rpS6) leading to increased translation of ribosomal and transcription factor mRNA resulting in protein translation initiation."
sparser
"Well-characterized effector targets of mTORC1 includes 4E-BP1 (4E-binding protein), ribosomal protein S6 kinase and S6K1 (p70S6 kinase) which, in turn, phosphorylates the ribosomal protein S6 (S6/RPS6) ( xref )."
sparser
"S6K1 phosphorylates the S6 protein of the 40s ribosomal subunit at several sites, including Ser 235/236 and Ser 240/244, leading to the initiation of protein synthesis [ xref ]."
reach
"mTOR is the key component of mTORC1 complex that promotes protein synthesis largely through the phosphorylation of two effectors, p70 S6 kinase (S6K1, which further phosphorylates S6) and 4E-BP1 [XREF_BIBR]."
sparser
"S6 is phosphorylated by S6K1, which itself is a target of mTOR."
reach
"mTORC1 activates p70S6K, which in turn phosphorylates the ribosomal protein S6 and 4E-BP1, both involved in protein translation."
sparser
"We have recently identified S6K2, a homolog of S6K1, which phosphorylates S6 in vitro and is regulated by the phosphatidylinositide 3-kinase (PI3-K) and mammalian target of rapamycin pathways in vivo."
reach
"The activated S6K1 phosphorylates ribosomal protein S6 (RpS6), and promotes protein translation."
reach
"Based on our data pointing to critical involvement of mTOR signaling in TTL short / high-risk leukemia, we addressed mTOR pathway activity by investigating phosphorylation of key signaling molecules : ribosomal protein S6 (S6), a downstream molecule which is phosphorylated by the ribosomal protein S6 kinase (p70S6K1) upon mTOR activation; and AKT, an upstream signaling kinase that is activated by phosphatidylinositol 3-kinase (PI3K) also mediating mTOR activation."
sparser
"Upon activation by receptor tyrosine kinases or G-protein coupled receptors, AKT activates mTOR, which in turn stimulates protein translation through inhibitory phosphorylation of eukaryotic translational initiation factor eIF4E-binding protein 1 (4E-BP1) that inhibits eIF4E, and activating phosphorylation of p70S6 kinase (S6K) that phosphorylates ribosomal S6 protein."
reach
"The inhibitor of RPS6KB1, LY2584702, significantly reduced the phosphorylation of RPS6KB1 and rpS6 in NSCLC cell lines."
reach
"Furthermore, siRNA mediated knockdown of S6K1 reduced phosphorylation of its substrate RPS6 without altering phosphorylation of 4E-BP1, and suppressed both basal rDNA transcription and 47/45S rRNA synthesis in the presence of amino acids (Lane 2 vs. Lane 4)."
sparser
"We conclude that Tyr-phosphorylated insulin receptor substrate-1 is the main upstream regulator of insulin-induced S6 phosphorylation by p70s6k, whereas MAPK signaling seems to be activated in these cells primarily through the adaptor molecule Shc."
biopax:netpath
No evidence text available
sparser
"Activated mTOR induces phosphorylation of p70S6K followed by p70S6K-induced phosphorylation of S6 and the eukaryotic translation initiation factor 4B (eIF-4B), which promotes protein translation ( Wan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
reach
"In the present study, we have examined whether Ang II activates p70 S6 kinase (p70S6K), which has been reported to phosphorylate S6 protein."
sparser
"Similarly, an inhibitor of p70 S6 kinase (PF-4708671) partially inhibited phosphorylation of S6 and preserved RP, while only marginally prevented cyclin D1 induction."
reach
"The S6 protein is a component of the 40S ribosomal subunit and, as phosphorylation of the S6 protein by p70S6K correlates with increased translation, this suggests one possible mechanism by which rapamycin could inhibit translation."
reach
"In turn, phosphorylated (P-) p70S6K phosphorylates S6 ribosomal protein (S6RP), which also stimulates translation."
reach
"Cell proliferation requires the co-ordinate triggering of several protein kinases of Ser/Thr specificity such as p70 S6 kinase (S6K), which phosphorylates the ribosomal S6 protein and thus increases translation of mRNAs with polypyrimidine tracts."
sparser
"mTOR also activates S6K-1, which phosphorylates ribosomal protein S6, resulting in increased translation."
reach
"The most well characterized rapamycin sensitive mTORC1 target is S6K1, a protein kinase that phosphorylates the ribosomal subunit S6 to control translation initiation."
sparser
"mTOR-activated p70S6K phosphorylates ribosomal protein S6 and directly phosphorylates mTOR at Serine 2448 ( xref , xref ), although the biological significance of mTOR S2448 phosphorylation is not fully understood."
sparser
"Phosphorylated S6K1 in turn phosphorylates S6 (40S ribosomal protein S6), enhancing the translation of mRNAs, while phosphorylation of 4EBP1 suppresses its ability to act on downstream effectors."
sparser
"mTOR activates the downstream p70S6 Ser/Thr kinase that phosphorylates ribosomal protein S6, required for biosynthesis of the cell's translational apparatus, a critical component of cell growth and proliferation xref ."
reach
"P70S6K phosphorylates ribosomal protein S6, in vivo, which has been implicated in stimulating the translation of mRNA transcripts that contain a polypyrimidine tract at their 5 ' transcriptional start[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
sparser
"P70S6K phosphorylates ribosomal protein S6 (S6) to promote protein synthesis (Taniguchi et al ., xref )."
reach
"While S6 is predominantly phosphorylated by p70S6K in most mammalian adult tissues, phosphorylation of S6 by p90rsk is important during meiosis in mammalian and amphibian oocytes [XREF_BIBR, XREF_BIBR], and to a lesser extent in growth factor stimulated hepatocytes [XREF_BIBR]."
sparser
"Rapamycin effectively inhibited rpS6 phosphorylation by WT S6K1 or WT S6K2 but did not affect rpS6 phosphorylation in cells expressing the activated, rapamycin-resistant forms of S6K1 or S6K2."
reach
"In LN229 and GAMG glioblastoma cells treated with either non targeting or PTEN targeting siRNA (siNT and siPTEN, respectively), both AD80 and LY-2779964 (LY64) were effective in reducing the S6K1 dependent phosphorylation of the ribosomal protein S6 (rpS6) at 3 hours (XREF_FIG, XREF_SUPPLEMENTARY)."
reach
"mTORC1 kinase activation causes the phosphorylation of the kinase p70S6K, which then phosphorylates the ribosomal protein S6."
sparser
"S6K1 phosphorylates ribosomal protein S6 (RPS6), which can increase translation rates by stimulation of ribosome biogenesis facilitated by increased translation of mRNAs containing 5′ (TOP) sequences."
sparser
"It is known that mTOR phosphorylates p70S6K followed by p70S6K-induced phosphorylation of eIF4B and S6 ( xref ) ( xref )."
reach
"Active mTORC1 phosphorylates p70S6K and, in turn, activated p70S6K phosphorylates RPS6 XREF_BIBR."
rlimsp
"S6K1 phosphorylates ribosomal protein S6 (rpS6) leading to increased translation of ribosomal and transcription factor mRNA resulting in protein translation initiation."
reach
"mTORC1 phosphorylates the p70S6 kinase (p70S6K), which in turn phosphorylates the S6 ribosomal protein and 4E-BP1, leading to protein translation."
reach
"Alterations in cell size are associated with changes in activity of mTORC1 acting through its downstream targets S6Kinase1 (S6K1), which phosphorylates ribosomal S6 protein (RPS6), and 4EBP1."
sparser
"P70 S6 kinase 1 (S6K1), another downstream effector of mTORC1, phosphorylates ribosomal protein S6, which also is associated with increased translation ( xref , xref )."
reach
"mTOR also allows translation initiation by phosphorylating and activating the kinase p70S6K which in turn phosphorylates the 40S ribosomal subunit S6 protein 30."
reach
"Growth factors and mitogens influence signaling pathways and often induce the activity of p70S6 kinase (p70S6K), which in turn phosphorylates the ribosomal S6 protein (S6)."
reach
"S6K-1, which is phosphorylated and activated by mTOR, in turn, phosphorylates ribosomal protein S6, which is a commonly used readout of mTOR activity."
reach
"Consequently, p70S6K phosphorylates ribosomal protein S6, resulting in increased translation of mRNA messages containing 5 ' terminal oligopolypyrimidine (5 ' TOP) tracts."
reach
"The activated S6K1 can phosphorylate downstream molecule ribosomal protein S6 (RpS6) to promote protein translation."
reach
"For example, p70 S6 kinase 1 (p70S6K) phosphorylates the S6 protein, a component of the 40S ribosomal subunit, and is an intermediary between mTOR and pS6."
sparser
"mTOR phosphorylates p70S6K, which in turn phosphorylates the S6 protein in the 40S small ribosomal subunit."
sparser
"Since p70S6K can also phosphorylate rpS6, the actual effect of the RSK inhibitors on rpS6 phosphorylation could be masked."
sparser
"While p70S6K can phosphorylate RPS6 at all sites, S235/236 is a specific target for RSK [ xref ]."
reach
"Another well established target of the TORC1 complex is the S6 protein kinase S6K1, which phosphorylates ribosomal protein S6, an event that controls elongation factor 2 kinase, but probably not translation of mRNAs with a 5 '-oligopyrimidine tract as originally suggested [XREF_BIBR - XREF_BIBR]."
reach
"LN-18 cells were transfected and serum starved before pretreatment with rapamycin to prevent p70S6K dependent phosphorylation of rpS6."
sparser
"Both RSK and S6K1 phosphorylate and activate the ribosomal subunit S6, which is essential for translation."
sparser
"We also studied the effects of RSK on the phosphorylation of rpS6 (S235/236) without the inhibition of p70S6K, which also phosphorylates the same residues of rpS6."
reach
"mTOR also activates S6K-1, which phosphorylates ribosomal protein S6, resulting in increased translation."
reach
"The p70 S6 kinase (p70S6K), which is activated by mTOR and phosphorylates RPS6, is also inhibited in SU-DHL-1 cells treated with U0126 [XREF_BIBR], but surprisingly not in the SR-786 ALK+ ALCL cell line [XREF_BIBR]."
sparser
"Activated RPS6KB1 phosphorylates ribosomal protein S6 leading to an increase in protein synthesis, cell growth/size, and cell survival xref ."
reach
"Genetic reduction of S6K1 in Fmr1-KO mice prevents the increased phosphorylation of S6 and eIF4B and the increased levels of eEF2, and this correlates with the resetting of protein synthesis to levels comparable to those in wild-type mice 15."
reach
"S6K1 (p70S6 kinase) phosphorylates S6 which controls the translation of mRNA that possesses an unusual oligopyrimidine tract at its transcription starting site termed 5 ' TOP."
sparser
"LN-18 cells were transfected and serum-starved before pretreatment with rapamycin to prevent p70S6K-dependent phosphorylation of rpS6."
sparser
"S6K1 phosphorylates the S6 protein of the 40s ribosomal subunit at several sites, including Ser 235/236 and Ser 240/244, leading to initiation of protein synthesis ( xref ; xref )."
reach
"As expected, inhibition of mTORC1 greatly inhibited both p70S6K and S6 phosphorylation, whereas inhibition of p70S6K diminished S6 phosphorylation without impairing mTORC1 activity (as judged by p70S6K phosphorylation)."
reach
"P70 S6 kinases phosphorylate the 40S ribosomal subunit protein S6 and activate the translation of mRNA containing 5 ' ligopyrimidine tracts."
sparser
"Activated mTOR phosphorylates p70 ribosomal protein S6 kinase (p70S6K) followed by p70S6K-induced phosphorylation of ribosomal protein S6 and eukaryotic initiation factor 4B (eIF-4B) which promotes the initiation of protein translation."
sparser
"These data suggest that SIRT1 deacetylates S6K1 in ISCs during CR to facilitate Thr389 phosphorylation by mTORC1 and S6 phosphorylation by S6K1 resulting in ISC expansion."
sparser
"Phosphorylation by mTORC1 at Thr389 activates p70S6K, which in turn phosphorylates ribosomal protein S6, and may influence translation of TOP RNAs ( xref ; xref ; xref ; xref ) ."
reach
"Phospho-S6K1 phosphorylates S6, a key component of ribosome, whose phosphorylation is critical for the reconstitution of ribosome and for protein synthesis."
sparser
"In particular, phosphorylated p70S6K enhances phosphorylation and activity of ribosomal protein S6 and initiates various translation activities required for cell growth."
sparser
"Increased mTORC1 activity ultimately results in the phosphorylation of multiple protein substrates, including p70S6K; when activated, p70S6K phosphorylates its substrate RPS6."
reach
"On activation, PI3-K phosphorylates inositol lipids that act as second messengers to activate different downstream effector kinases such as the PKB and AKT kinase, which is involved in cell survival, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
reach
"This complex directly phosphorylates p70 ribosomal protein S6 kinase 1 (p70S6K1, phosphorylates ribosomal protein S6) and eukaryote translation initiation factor 4E binding protein 1 (4E-BP1) to regulate cell growth and survival [XREF_BIBR]."
reach
"P70S6K subsequently phosphorylates the ribosomal S6 subunit (S6) [20, 23-26]."
sparser
"During the activation of mTORC1, its substrate p70S6K phosphorylates ribosomal protein S6 [ xref ]."
reach
"PF-4708671 is a specific inhibitor of S6K1, and prevents S6K1 mediated phosphorylation of the S6 protein."
sparser
"mTOR phosphorylates downstream targets such as p70S6 kinase (p70S6K) which then phosphorylates ribosomal protein S6 (S6) [ xref ]."
sparser
"Activation of mTOR leads to the phosphorylation of eukaryotic translation initiation factor eIF4E-binding protein 1 (4E-BP1) and p70S6K which phosphorylates S6. xref , xref xref show that pp70S6K-Thr-389/p70SK protein ratios were increased 1.8- and 3.1-fold in 1- and 10-day-old mutant hearts compared to wild-type, respectively."
reach
"Together, these results suggest either that the FL772 inhibitor has poor cell membrane permeability or that inhibition of S6K1 in cells does not significantly reduce S6 phosphorylation."
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR S6K1 phosphorylates S6, which regulates the translation of 5 ' terminal oligopyrimidine mRNAs that encode ribosomal proteins and translation factors."
reach
"P70S6K phosphorylates and activates S6, a ribosomal subunit involved in initiating translation of 5 ' terminal oligopyrimidine tract containing mRNA encoding components of the protein synthesis machinery."
reach
"Furthermore mTORC1 phosphorylates and activates p70S6 kinase (p70S6K) which in turn phosphorylates the ribosomal protein S6 (RPS6), a component of the 40S ribosomal protein which regulates the initiation of protein translation."
sparser
"Consequently, p70S6K phosphorylates ribosomal protein S6, resulting in increased translation of mRNA messages containing 5′ terminal oligopolypyrimidine (5′TOP) tracts."
reach
"CK2-inhibition strongly reduces rpS6 phosphorylation without affecting p70S6K, the main kinase active on this protein in R-KCL22 cells as indicated by cell treatment with rapamycin and PF-4708671."
sparser
"S6K1 phosphorylates ribosomal protein S6, in some models enhancing the translation of mRNAs possessing a 5′ terminal oligopyrimidine tract ( xref )."
sparser
"Once phosphorylated, 4E-BP1 dissociates from eIF4E whereas p70S6K phosphorylates ribosomal protein S6, thus promoting mRNA translation [ xref ]."
sparser
"Phosphorylated S6K1 further phosphorylates ribosomal protein S6 (S6) to promote ribosome biogenesis."
sparser
"S6K1 phosphorylates multiple sites of the 40 S ribosomal protein S6 resulting in a specific increase in the translation of a subset of mRNAs containing a polypyrimidine tract in their 5′-untranslated region (5′ TOP mRNAs) xref ."
sparser
"Activated S6K1 phosphorylates ribosomal protein S6, which promotes production of ribosomal proteins and elongation factors to increase translation [ xref , xref , xref ]."
reach
"Active p70S6K phosphorylates the ribosomal protein S6, enhancing translation of mRNA transcripts involved in cell cycle progression."
sparser
"S6K1 phosphorylates ribosomal protein S6 (rpS6) leading to increased translation of ribosomal and transcription factor mRNA resulting in protein translation initiation."
sparser
"Unstimulated COS cells contain active p70S6K, which phosphorylates ribosomal S6 protein as well as CREM in vitro (Figure 3A)."
sparser
"S6K1 phosphorylates and activates S6, a ribosomal subunit involved in initiating protein synthesis machinery."
sparser
"It is a serine/threonine kinase, which phosphorylates at least three downstream substrates: the translation repressor eIF4E-binding protein (4E-BP) ( xref ; xref ; xref ); p70S6K, which phosphorylates ribosome protein S6 ( xref ); and signal transducer and activator of transcription 3 (Stat3) ( xref ; xref )."
reach
"In mammalian cells, mTORC1 phosphorylates proteins involved in protein synthesis and cell growth, including p70S6K1, which phosphorylates the ribosomal protein S6."
sparser
"mTORC1 phosphorylates proteins involved in protein synthesis and cell growth, including 4E-BP1 and p70S6 kinase 1 (S6K1), which phosphorylates the ribosomal protein S6."
reach
"Transfection studies showed that TRAF4 functions in p70S6K activation : TNF induced phosphorylation of S6, the main intracellular substrate of the kinase, in cells stably expressing TRAF4, but not in TRAF4 negative cells."
sparser
"The activated S6K1 phosphorylates ribosomal protein S6 (RpS6), and promotes protein translation."
reach
"S6 phosphorylation is mediated by the 70-kD ribosomal S6 kinase 1 (S6K1) which requires phosphorylation at its " T loop " site by PDK1."
reach
"Activation of mTOR results in the phosphorylation and activation of S6K1, which in turn phosphorylates ribosomal protein S6, and finally stimulates translation initiation and protein synthesis."
sparser
"In turn S6K1 phosphorylates and activates S6, a ribosomal protein involved in translation xref , xref , xref ."
sparser
"mTOR complex 1 (mTORC1) promotes phosphorylation (activation) of p70 S6 kinases (p70S6Ks) that phosphorylate the small ribosomal subunit protein S6 (Rps6), and this was proposed to promote translation of TOP mRNAs."
reach
"We demonstrate that while ribosomal S6 kinase 1 (S6K1) phosphorylates rpS6 at all sites, RSK exclusively phosphorylates rpS6 at Ser (235/236) in vitro and in vivo using an mTOR independent mechanism."
reach
"256 Mitogenic stimulation causes S6 C-terminal phosphorylation by p70 S6 kinases (S6Ks) and p90 ribosomal S6 kinases (RSKs) on Ser 235, Ser 236, Ser 240, and Ser 244."
reach
"S6 phosphorylation is mediated by S6K1, which requires phosphorylation at its ' T loop ' site by PDK1."
reach
"However, S6 phosphorylation by S6K1 is only minimally influenced by removal of the CTD, or by phospho defective or -mimetic mutations."
sparser
"Two primary effectors of mTORC1 signaling are p70S6 kinase, which phosphorylates the ribosomal protein S6, and 4E-BP1 that controls formation of the translation initiation complex xref ."
sparser
"One clue, involving translational control, is the activation of p70 S6 kinase, which phosphorylates the ribosomal S6 protein ()."
reach
"The p70 S6 kinase (p70S6K), which is activated by mTOR and phosphorylates RPS6, is also inhibited in SU-DHL-1 cells treated with U0126 [XREF_BIBR], but surprisingly not in the SR-786 ALK+ ALCL cell line [XREF_BIBR]."
reach
"A number of studies in which either or both S6K genes have been deleted in mice suggest that the control of cell growth is a non redundant function specific to S6K1, while phosphorylation of the canon[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
reach
"S6K1, in turn, phosphorylates its target - ribosomal protein S6 - on serines 240 and 244 (Ser240 and Ser244) and serines 235 and 236 (Ser235 and Ser236) [XREF_BIBR - XREF_BIBR]."
reach
"S235/236 of rpS6 can be phosphorylated by p70S6K and/or RSK."
sparser
"Potential downstream targets of PI3-kinase activity include: p70 kinase phosphorylates the 40S ribosomal protein S6 in response to mitogenic stimuli and plays a key role in G1 to S phase transition th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
reach
"The most well characterized rapamycin sensitive mTORC1 target is S6K1, a protein kinase that phosphorylates the ribosomal subunit S6 to control translation initiation."
reach
"Likewise, activated S6K1 phosphorylates ribosomal protein S6 that also participates in translation initiation."
reach
"This subsequently leads to increased phosphorylation of eIF4E binding protein 1 (4EBP1) and activation of p70 ribosomal S6 protein kinase (p70 S6K), which phosphorylates S6 ribosomal protein XREF_BIBR."
sparser
"This second phosphorylation fully activates the S6K1 kinase which can then phosphorylate eIF4B, S6 and other protein targets."
| PMC
reach
"P70S6K is activated by mTORC1 and phosphorylates S6."
reach
"Importantly, S6K1 short isoforms are catalytically inactive and did not induce phosphorylation of the known S6K1 substrates, the ribosomal protein S6 or mTOR itself in an in vitro kinase assay and upo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
reach
"S6K1 knockdown led to decreased S6 phosphorylation but increased the levels of LC3-II."
biopax:netpath
No evidence text available
reach
"S6K1 phosphorylates ribosomal protein S6 (S6) and enhances the translation of mRNAs [XREF_BIBR, XREF_BIBR]."
reach
"P70S6 kinase phosphorylates ribosomal protein S6, and possibly the initiation factors eIF4B and eIF4G."
reach
"S6K1 phosphorylates ribosomal protein S6 (RPS6) which is an essential component of the 40S ribosomal subunit."
reach
"Active mTORC1 also phosphorylates and activates p70S6K which in turn phosphorylates ribosomal protein S6 to enhance translation efficiency 6."
sparser
"Treatment of cells with the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] or rapamycin, an inhibitor of mammalian target of rapamycin and ribosomal p70 S6 kinase (p70S6K) phosphorylation, or with an adenovirus containing green fluorescent protein and a dominant-negative and kinase-dead Akt, effectively inhibited the insulin-mediated increase in alpha-class GST expression and GST activity toward NBD."
sparser
"S6K1 phosphorylates the S6 ribosome, thus stimulating protein synthesis."
sparser
"S6 is phosphorylated by both S6K1 and the closely related S6K2 on Ser 240 /Ser 244 as well as Ser 235 /Ser 236 ."
reach
"This indicates that p70S6K1 activated by Abeta phosphorylates the ribosomal S6 protein and 4E-BP1, which in turn prevents the interaction between 4E-BP1 and eIF-4E ultimately to enhance the cap dependent mRNA translation of HIF1alpha and HIF1alpha synthesis."
sparser
"Whereas mTORC1-mediated phosphorylation of 4E-BP1 induces its dissociation from eIF4E, the rate-limiting factor for initiation of Cap-dependent translation ( xref ), phosphorylated S6K1 phosphorylates ribosomal protein S6, an essential regulator of protein translation and cell growth ( xref )."
sparser
"Activated mTORC1 phosphorylates S6Ks, which in turn phosphorylate the ribosomal protein S6 and other substrates involved in protein and lipid biosynthesis ( xref )."
reach
"Akt mediated phosphorylation of the mTOR phosphorylates the p70S6K which is known to phosphorylate the ribosomal protein S6 and consequently results in ribosome biogenesis and protein synthesis."
reach
"In mammals, upon stimulation by growth factors including insulin, the mammalian TOR (mTOR) cooperates with PI3K dependent effectors to activate p70 ribosomal protein S6 kinase 1 (S6K1), thereby phosphorylating the 40S-ribosomal protein S6, and subsequently enhances translation of the 5 '-terminal oligopyrimidine (5 '-TOP) sequences that encode components of the translational machinery."
sparser
"P70S6 Kinase phosphorylates the 40S ribosomal subunit protein S6 and thereby allows translation of proteins involved in cell growth and hypertrophy."
sparser
"These results show that haloperidol promotes mTORC1- and S6K1-dependent phosphorylation of rpS6 at Ser240/244, in a subpopulation of striatal MSNs expressing D2Rs."
reach
"S6K1 phosphorylates ribosomal protein S6, in some models enhancing the translation of mRNAs possessing a 5 ' terminal oligopyrimidine tract."
sparser
"Upon activation, p70S6K directly phosphorylates the 40S ribosomal protein S6, which correlates with enhanced translation of transcripts with a 5'-terminal oligopyrimidine tract, such as elongation factor-1 alpha and ribosomal proteins [ xref ]."
sparser
"S6K1 in turn phosphorylates the ribosomal protein S6 ( xref )."
reach
"Silencing of S6K1 or S6K2 effectively depleted the homolog and attenuated phosphorylation of the substrate S6."
reach
"One of these enzymes was MAP k inase- a ctivated p rotein k inase- 1 (MAPKAP-K1, also known as p90 rsk), a component of the classical MAP kinase cascade, while the other was p70 S6 kinase, the enzyme [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
reach
"The mTORC1 controls the rate of protein synthesis through phosphorylation and activation of its substrates, p70S6 ribosomal kinase 1 (p70S6K) and eukaryotic translation initiation factor 4E (eIF4E) binding protein-1 (4E-BP1) and once phosphorylated, p70S6K phosphorylates ribosomal protein S6 and 4E-BP1 becomes dissociated from eIF4 and promote mRNA translation and protein synthesis [XREF_BIBR]."
sparser
"As indexed to actin and compared to SHAM mice, abundance of total S6K1 and S6 but not Thr389 phosphorylated S6K1 or Ser235/236 phosphorylated S6 were increased in HF ( xref )."
sparser
"Adiponectin enhances insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1 [ xref ] but systemic adiponectin levels are not influenced by carbohydrate uptake."
reach
"The p70 and p85 S6 kinase 1 (S6K1), which is able to catalyze the phosphorylation of rpS6 at all sites, was the first kinase identified."
sparser
"P70S6k sequentially phosphorylates the S6 kinase that induces ribosomal proliferation."
reach
"The p70-S6K1 protein is activated by mTOR and subsequently phosphorylates the ribosomal S6 protein (RPS6), eukaryotic transcription initiation factor 4B (EIF4B), and eukaryotic elongation factor 2-kinase (eEF2k) and is a positive regulator of protein translation."
sparser
"Also, downstream of mTOR and PI3K are S6K1 and S6K2, which phosphorylate the ribosomal protein S6 [3] ."
sparser
"Therefore, we might hypothesize that the phosphorylation of rpS6 by p70S6K is under the control of a CK2-mediated regulatory mechanism."
reach
"The C1 prototype is responsible for activating p70S6K, which in turn phosphorylates the ribosomal protein S6 and 4E-BP1 -- which is inhibited by rapamycin (Corradetti et al., 2006; Gera and Lichtenste[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
sparser
"The antagonist effect of dominant kinase deficient PKC shows PKC can activate p70 and acts to integrate signals through PI3K and the Rapamycin sensitive pathway detailed previou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
reach
"P70S6K, activated by mTOR, phosphorylates S6 ribosomal protein to regulate translation of 5 '-TOP mRNA and ribosome biogenesis [XREF_BIBR]."
reach
"P70 S6 phosphorylates the 40S ribosomal subunit protein S6 and stimulates the translation of the 5 ' oligopyrimidine tract containing mRNAs [XREF_BIBR]."
sparser
"For example, p70 S6 kinase 1 (p70S6K) phosphorylates the S6 protein, a component of the 40S ribosomal subunit, and is an intermediary between mTOR and pS6."
reach
"Upon activation, S6K1 phosphorylates ribosomal protein S6 (RPS6) to stimulate ribosomal biogenesis [XREF_BIBR], eukaryotic elongation factor 2 kinase (eEF2K) to de-repress translational elongation [XREF_BIBR], as well as eIF4B to heighten translational initiation [XREF_BIBR, XREF_BIBR]."
sparser
"The active form of S6Ks then phosphorylates ribosomal protein S6 and increases general protein synthesis."
rlimsp
"In mammalian cells, mitogen-induced phosphorylation of ribosomal protein S6 by p70s6k has been implicated in the selective translational upregulation of 5'TOP mRNAs."
reach
"Active mTORC1- consisting besides the mTOR kinase itself, of Raptor and PRAS40 as well as other regulatory proteins [XREF_BIBR] -- phosphorylates proteins such as 4E-BP1 and S6 kinase 1 (S6K1), which in turn phosphorylates the ribosomal protein S6."
sparser
"S6K1, a key regulator of cell growth, phosphorylates ribosomal protein S6 and enhances the translation of 5’-terminal oligopyrimidine tract mRNAs in some models ( xref )."
reach
"mTOR triggers activity of ribosomal S6 kinase-1 (S6K1), which phosphorylates the ribosomal protein S6, promoting ribosomal biogenesis and protein translation."
sparser
"These results are consistent with the conclusion that phosphorylation of S6(S240) by S6K1 is an essential prerequisite for subsequent phosphorylation of S6(S235) by RSK."
reach
"Activated mTORC1 increases protein synthesis by directly phosphorylating the ribosomal S6 kinase 1 (S6K1), which in turn directly phosphorylates ribosomal protein S6, resulting in increased ribosomal protein translation."
reach
"AA signaling is integrated by the mammalian target of rapamycin (mTOR), and mTOR is involved in the sensing of nutrient availability and modulation of insulin action in vivo via its further effects to activate S6 kinase 1 (S6K1), which phosphorylates the S6 ribosomal protein to enhance protein synthesis."
biopax:netpath
No evidence text available
reach
"S6K1 (p70S6 kinase) phosphorylates S6 which controls the translation of mRNA that possesses an unusual oligopyrimidine tract at its transcription starting site termed 5 ' TOP."
reach
"The S6 ribosomal protein belongs to the PI3K/AKT/PTEN/mTOR signaling pathway and is phosphorylated by p70 S6 kinase when this pathway is activated."
reach
"PF-4708671, a specific inhibitor of S6K1, modestly inhibited S6 phosphorylation but induced the feedback activation of the PI-3 kinase pathway, evidenced by increased AKT and S6K1 phosphorylation."
reach
"In response to numerous intracellular and extracellular stimuli, mTORC1 phosphorylates eukaryotic initiation factor 4E binding protein-1 (4E-BP1) and S6 kinase 1 (S6K1), which exerts an essential role in increasing translation of a subset of mRNAs and accelerating growth and proliferation XREF_BIBR XREF_BIBR."
reach
"Upon activation by mTOR, S6K1 phosphorylates S6 ribosomal protein, leading to increased translation of mRNA with oligopyrimidine tract at the 5 ' terminal (5 ' TOP) [XREF_BIBR]."
reach
"The best known rapamycin sensitive mTORC1 target is S6K1, a protein kinase that phosphorylates the ribosomal subunit S6 to control translation initiation."
reach
"Activation of p70S6K by mTORC1 via phosphorylation at threonine 389 promotes phosphorylation and activation of ribosomal protein S6 (rpS6) and eukaryotic initiation factor 4B (eIF4B)."
reach
"The p70 and p85 S6 kinase 1 (S6K1), which is able to catalyze the phosphorylation of rpS6 at all sites, was the first kinase identified."
reach
"mTOR phosphorylates S6K1 at T389 to enhance S6K1 activity, which amongst other things phosphorylates the S6 subunit of the ribosome to promote translation."
reach
"XREF_FIG, S6K1 siRNA reduced S6K1 expression and S6 phosphorylation but increased AKT phosphorylation and LC3-II lipidation."
sparser
"The activated S6K1 can phosphorylate downstream molecule ribosomal protein S6 (RpS6) to promote protein translation."
sparser
"In mammalian cells, mTORC1 phosphorylates proteins involved in protein synthesis and cell growth, including p70S6K1, which phosphorylates the ribosomal protein S6."
reach
"It was originally thought that the phosphorylation of S6 by S6K1 was responsible for the translation of TOP mRNAs."
sparser
"mTORC1 kinase activation causes the phosphorylation of the kinase p70S6K, which then phosphorylates the ribosomal protein S6."
reach
"Both leucine and isoleucine have been shown to enhance the fractional protein synthesis rates in bovine mammary cells with the phosphorylation of mTOR and rpS6, or mTOR, S6K1, and rpS6 respectively [XREF_BIBR], while decreasing the abundance of proteasome protein, ubiquitinated protein, and the rate of protein degradation [XREF_BIBR]."
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"Growth factors and mitogens influence signaling pathways and often induce the activity of p70S6 kinase (p70S6K), which in turn phosphorylates the ribosomal S6 protein (S6)."
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"Thus, S6 phosphorylation does not occur through ERK regulated p90S6K but rather is mediated by p70S6K."
reach
"For instance, in an mTOR independent manner, phospholipase D-2-derived phosphatidic acid directly binds and activates p70S6K, 55 and p90 ribosomal S6 kinases directly phosphorylate RPS6."
sparser
"Importantly, inhibition of PI3K pathway activation by GDC-0941 was clearly manifested by decreases in ribosomal p70 S6 kinase (S6 kinase) phosphorylation (p-S6 kinase, Ser235/236 and Ser240/244), particularly in the 5-FU-tolerant cells."
sparser
"Activation of mTOR leads to phosphorylation of several proteins, including p70 ribosomal S6 (phospho-S6) kinase which phosphorylates ribosomal protein S6 thereby resulting in increased protein translation and cell growth."
sparser
"P70S6K phosphorylates and activates ribosomal protein S6 (S6), a component of the 40S ribosomal subunit , and phosphorylates the eukaryotic initiation factor 4B (eIF4B), a regulator of protein synthes[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
sparser
"In response to mitogenic stimuli, p70S6K phosphorylates S6 on multiple sites, and it is believed that these modifications favor the recruitment of the 40S subunit into actively translating polysomes [[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"S6K1 phosphorylates multiple sites of the 40 S ribosomal protein S6 resulting in a specific increase in the translation of a subset of mRNAs containing a polypyrimidine tract in their 5 '-untranslated region (5 ' TOP mRNAs) XREF_BIBR."
biopax:netpath
No evidence text available
reach
"mTOR activation has been linked to cardiac hypertrophy by phosphorylating downstream targets including eukaryotic initiation factor 4E binding protein 1 (4E-BP1) and ribosomal S6 kinase (p70S6K), which leads to increased phosphorylation of ribosomal protein S6 (S6)."
reach
"S6 is phosphorylated by S6K1, which itself is a target of mTOR."
sparser
"P70S6, a serine/threonine kinase, is a downstream signal of the PI3K/Akt/mammalian target of rapamycin and mitogen-activated protein kinase cascades. xref On activation, p70S6 subsequently phosphorylates ribosomal protein S6, which, in turn, promotes protein translation and cell growth. xref In addition, we also found that boehmenan remarkably inhibited the expression of p-Akt, p-70S6, and p-S6, which is critical for cell survival and resistant to apoptosis. xref Thus, suppression of STAT3 and PI3K/Akt pathway contributed to cell apoptosis and inhibition of cell survival triggered by boehmenan."
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"P70S6 kinase phosphorylates the ribosomal protein S6 with subsequent enhancement of translation of mRNAs bearing a 5 '-terminal oligopyrimidine tract."
reach
"mTOR promotes new protein synthesis by targeting the eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and S6 kinase 1 (S6K1), which in turn phosphorylates S6."
reach
"mTORC1 consists of mTOR, mLST8, Raptor, Deptor, and PRAS40 and phosphorylates the elF4E binding protein (4F-BP) and p70 S6 kinase 1 (S6K1), a serine/threonine kinase that phosphorylates the ribosomal protein S6."
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"RPS6 is phosphorylated by p70S6K, which in turn is activated by mTOR (Hay and Sonenberg, 2004)."
sparser
"P70S6K phosphorylates ribosomal protein S6, in vivo, which has been implicated in stimulating the translation of mRNA transcripts that contain a polypyrimidine tract at their 5′ transcriptional start [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"S6K1 deficient mice phosphorylated S6 but had a small body phenotype."
reach
"Increased mTORC1 activity ultimately results in the phosphorylation of multiple protein substrates, including p70S6K; when activated, p70S6K phosphorylates its substrate RPS6."
reach
"mTORC1 phosphorylates the p70S6 kinase (p70S6K), which in turn phosphorylates the S6 ribosomal protein and 4E-BP1, leading to protein translation."
sparser
"RPS6 is phosphorylated by p70S6K, which in turn is activated by mTOR ( xref )."
reach
"Stimulation of mammalian cells with growth factors or amino acids leads to phosphorylation and activation of p70 S6 kinase, which in turn phosphorylates the ribosomal protein S6 (Chung et al., 1992; J[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
sparser
"P70S6K subsequently phosphorylates the ribosomal S6 subunit (S6) [ xref , xref – xref ]."
reach
"S6K1 phosphorylates the ribosomal protein S6 (RPS6) thereby connecting the TOR pathway with ribosomes."
reach
"This result is consistent with the RxRxxS motif on S6 that is known to be phosphorylated by S6K1 (Flotow and Thomas, 1992)."
sparser
"Although both RSK2 and S6K1 phosphorylate S6 in vivo , these kinases do not appear to be functionally redundant for a few reasons."
biopax:netpath
No evidence text available
sparser
"Since LKB1 is a regulator of mTOR activity through the phosphorylation of the energy sensor AMPK, in the absence of this regulation, mTOR is active whereby it phosphorylates S6K1, that in turn phosphorylates pS6, ultimately leading to protein translation xref ."
sparser
"Treatment of mammalian cells with rapamycin abolishes in vivo S6 phosphorylation by p70s6k; however, ectopic expression of AtS6k2 rescues the rapamycin block."
reach
"A preponderance of evidence suggests that translation of mRNAs containing a 5 '-TOP signal is strongly up-regulated in response to ribosome protein S6 phosphorylation triggered by mTORC1 stimulation and subsequent S6K1 activation."
biopax:netpath
No evidence text available
reach
"S6K1 phosphorylates and activates S6, a ribosomal subunit involved in initiating protein synthesis machinery."
sparser
"mTORC1 phosphorylates and activates p70S6K which in turn phosphorylates ribosomal protein S6 to enhance translation efficiency xref ."
reach
"Phosphorylation activated p70S6K then phosphorylates S6 protein (small ribosomal S6) and eIF4B (eukaryotic translation initiation factor 4B)."
sparser
"For translational regulation, a clue as to how Rac acts may lie in its reported ability to interact with p70S6K , which phosphorylates the ribosomal protein S6 and thereby promotes the translation of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
reach
"While p70S6K phosphorylates ribosomal S6 protein potentially modulating its activity, 4EBP1 binds and inactivates a factor of initiation of Cap dependent transcription eIF4E."
sparser
"However an alternate event, p70 S6 kinase phosphorylation of IRS-1 on S636/639, could also occur resulting in decreased IGF-1R signaling."
reach
"Among many other functions, mTORC1 is best known to control protein synthesis through phosphorylation of the translational regulators 4E-BP1 and S6K1, the latter of which in turn phosphorylates the ribosomal protein S6 and other substrates."
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"Once activated, S6K1 phosphorylates S6."
reach
"mTOR allows eukaryotic cells to adjust their protein biosynthetic capacity XREF_BIBR, XREF_BIBR, XREF_BIBR through downstream effectors : (1) S6K1, a kinase that phosphorylates Rps6 and promotes protein synthesis and cell proliferation, and (2) eukaryotic translation initiation factor 4E binding protein 1 (4EBP1), a protein that prevents translation when its unphosphorylated form interacts with eIF4E XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"For example, mTOR activates ribosomal S6 kinase-1 (S6K1), which phosphorylates the ribosomal protein S6, promoting ribosomal biogenesis and protein translation."
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"For example, p70 S6 kinase 1 (p70S6K) phosphorylates the S6 protein, a component of the 40S ribosomal subunit, and is an intermediary between mTOR and pS6."
reach
"Well characterized effector targets of mTORC1 includes 4E-BP1 (4E binding protein), ribosomal protein S6 kinase and S6K1 (p70S6 kinase) which, in turn, phosphorylates the ribosomal protein S6 (S6/RPS6)."
sparser
"Activated S6K1 then phosphorylates eIF4B and the 40S ribosomal subunit protein S6."
sparser
"Phosphorylation of ribosomal protein S6 by p70 S6 kinase, which is believed to be involved in regulating 5′-TOP mRNA translation [ xref ], is one of the earliest events detected following mitogenic stimuli, as part of liver regeneration of following fasting and refeeding."
sparser
"Activated S6K1 phosphorylates S6 and other translational regulators such as eIF2 kinase and eIF-4B to regulate the translation initiation [ xref , xref ] and ribosomal biogenesis."
reach
"Similar to A77 1726, PF-4708671, a specific inhibitor of S6K1, inhibited S6 phosphorylation but induced the feedback activation of the PI-3 kinase pathway, as shown by increased AKT and S6K1 phosphorylation."
sparser
"Activated S6K1 phosphorylates S6 to promote ribosome biogenesis."
sparser
"In addition, NAD(P)H oxidase p22phox, p47phox, gp91phox expression, and mitogen-activated protein kinase and its downstream effector p70 S6 kinase phosphorylation in DS rats was also inhibited by telmisartan."
sparser
"Although S6Ks phosphorylate ribosomal protein S6, it is not clear whether or how this affects mRNA translation."
reach
"Key downstream targets that modulate protein translation include eukaryotic initiation factor 4E and p70S6 kinase, the latter of which phosphorylates ribosomal S6 protein."
sparser
"The p70-S6K1 protein is activated by mTOR and subsequently phosphorylates the ribosomal S6 protein (RPS6), eukaryotic transcription initiation factor 4B (EIF4B), and eukaryotic elongation factor 2-kinase (eEF2 k) and is a positive regulator of protein translation (reviewed in [ xref ])."
reach
"Upon activation by mTORC1, S6K1 phosphorylates S6 ribosomal protein to stimulate mRNA translation."
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"In conclusion, our data show that mTORC1 and S6K1 influence T cell activation and differentiation independently of their capacity to mediate rpS6 phosphorylation."
reach
"Both mTOR and Akt are upstream activators of translational regulators such as p70 S6-kinase, an enzyme that phosphorylates rpS6."
reach
"There are several documented downstream targets for Akt, including p70S6 kinase, which phosphorylates the S6 ribosomal protein (reviewed in [43])."