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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

IKK_complex binds PEBP1 and RAF1. 2 / 2

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"A high level of PEBP1 protein interacts with both Raf1 and IKK to inhibit the NF‐κB signaling cascade, resulting in the sequestration of p65/p50 heterodimer in the cytoplasm, thereby silencing HIV‐1 transcription."

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"Our data also supported that PEBP1 formed a protein complex with Raf1 and/or IKK to suppress NF‐κB signaling and induce HIV latency in CD4 + T cells."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...