IndraLab

Statements

USP9X inhibits ZBTB38. 4 / 4
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"The level of ZBTB38 protein was found to be very low in cells treated with siRNAs targeting USP9X, and the exposure to H 2 O 2 did not induce ZBTB38 accumulation in these cells."
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"Conversely, the depletion of USP9X further down-regulated the abundance of ZBTB38 protein in cells over-expressing RBBP6 (XREF_SUPPLEMENTARY)."
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"We noticed that ZBTB38 protein levels are regulated during the cell cycle : ZBTB38 expression was higher in S-phase cells (synchronized by hydroxyurea) than in M-phase cells (synchronized by nocodazole), and USP9X depletion significantly reduced ZBTB38 protein abundance in both cases."
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"These data indicate that the depletion of USP9X or the inhibition of its deubiquitinase activity prevents the accumulation of ZBTB38 induced by H 2 O 2 exposure."
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