IndraLab

Statements

USP8 deubiquitinates CHMP1B. 7 / 7
1 | 6
reach
"Thus, deubiquitination of CHMP1B by USP8 at the endosomal membrane may favor CHMP1B oligomerization and co-assembly with IST1 in vivo."
29933386
ubibrowser
"Based on these observations, we propose that <span class="match term1">CHMP1B</span> is dynamically regulated by ubiquitination in response to EGF and that <span class="match term0">USP8</span> triggers <span class="match term1">CHMP1B</span> deubiquitination possibly favoring its subsequent assembly into a membrane-associated ESCRT-III polymer."
29933386
reach
"By deubiquitinating CHMP1B, USP8 also indirectly regulates the deubiquitination of EGFR in the early endosomes [201] Indeed, USP8 activating variants result in increased EGFR recycling, which in turn leads to a rise in POMC transcription [11,12,183] (Figure 4)."
38067388
reach
"Based on these observations, we propose that CHMP1B is dynamically regulated by ubiquitination in response to EGF and that USP8 triggers CHMP1B deubiquitination possibly favoring its subsequent assembly into a membrane associated ESCRT-III polymer."
29933386
reach
"Our results thus strongly suggest that USP8 deubiquitinates CHMP1B."
29933386
reach
"Finally, we observed that the ubiquitination level of endogenous CHMP1B was higher in partially Usp8 silenced cells compared to control cells, strengthening the hypothesis that USP8 deubiquitinates CHMP1B (XREF_FIG)."
29933386
reach
"Furthermore, we have demonstrated that USP8 deubiquitinates CHMP1B."
29933386