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SMYD2 methylates TP53 on K370. 43 / 45
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"Moreover, p53 is methylated at lysine 370 by Smyd2, which appears not to alter p53 levels but acts in a repressive manner to decrease p53 DNA-binding ability [61] ."
19217357
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"SMYD2 also methylates p53 at lysine-370, providing regulatory cross-talk between PTM and tumor-suppressive function ( xref )."
37315132
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"However, the methylation at p53-K372 by KMT5 prevents the methylation at p53-K370 by KMT3C ( xref )."
18581285
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"P53 is methylated at K370 by Smyd2 (Set and MYND Domain-2), K372 by Set 7/9 (Su (var) 3-9 and " Enhancer of zeste " protein 7/9), and K382 by Set8 (Su (var) 3-9 and " Enhancer of zeste " protein 8) [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25545885
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"Conversely, methylation on K370 of human p53 by Smyd2 was shown to inhibit p53 activity ( Huang et al., 2006 )."
21855806
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"P53 is methylated at K370 by Smyd2, K372 by Set 7/9, and K382 by Set8 (ref. xref – xref )."
35487975
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"Smyd2 monomethylates p53 at lysine 370 [XREF_BIBR]."
24561874
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"Wang demonstrated that SMYD2 can methylate p53 at site K370 thereby inhibiting its transcriptional activity which promotes CC occurrence dependent on aerobic glycolysis 41."
38577616
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"P53 is methylated at K370 by Smyd2 (Set/MYND Domain-2), K372 by Set 7/9 (Su(var)3-9 and “Enhancer of zeste” protein 7/9), and K382 by Set8 (Su(var)3-9 and “Enhancer of zeste” protein 8) [ xref , xref , xref , xref , xref ]."
25545885
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"It is thought that mono-methylation by SMYD2 of lysine Lys 370 on p53 creates a steric blockage that impedes p53 from binding its target gene promoters, and knockdown of SMYD2 prevents DNA damage-induced, p53-dependent apoptosis ( xref )."
25825497
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"Moreover, p53 is methylated at lysine 370 by Smyd2, which appears not to alter p53 levels but acts in a repressive manner to decrease p53 DNA-binding ability [61] ."
19217357
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"However, methylation of p53-K370 by KMT3C and monomethylation of p53-K382 by KMT5A inhibit the transcriptional activation of p53 on p21, MDM2, and PUMA, resulting in p53-mediated cell cycle arrest and reduced cell apoptosis ( xref )."
37953778
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"SMYD2 mono-methylates p53 on lysine K370 (p53K370me1), xref , xref while SET7 monomethylates p53 on lysine K372 (p53K372me1) xref in the regulatory domain."
23625014
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"In this regard, it has been reported that SMYD2 can methylate p53 on Lys 370 and that this methylation leads to repression of its activity."
34143514
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"SMYD2 mono-methylates p53 on lysine K370 (p53K370me1), XREF_BIBR, XREF_BIBR while SET7 monomethylates p53 on lysine K372 (p53K372me1) XREF_BIBR in the regulatory domain."
23625014
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"Here we report that SMYD2 prefers to methylate p53 Lys 370 over histone substrates in vitro."
21880715
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"P53 is methylated at K370 by Smyd2, K372 by Set 7/9, and K382 by Set8 (ref."
35487975
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"Specifically, Set7/9 monomethylates p53 at K372 resulting in activation of p53 [ 44 ], whereas Smyd2 and Set8/PR-Set7 monomethylate p53 at K370 and K382 respectively and function to repress the activi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19179064
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"For instance, methylation of p53 on K370 by SMYD2 [ xref ] or on K382 by SETD8 [ xref ] results in transcriptional repression, whereas methylation at K372 by SET7/9 leads to activation of transcription [ xref ]."
21966347
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"SMYD2 also methylates non-histone targets, for example, SMYD2 mono-methylates K370 in p53 to reduce the DNA-binding efficiency of p53 [ xref ], and this protein also methylates K810 of RB1 or K313 of PTEN to enhance cell cycle progression or inactivate tumor suppression function of PTEN, respectively [ xref , xref ]."
37673879
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"KMT3C, a member of the Smyd (SET and MYND domain) subfamily of SET domain containing proteins, mono-methylates p53 at K370."
18581285
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"In the present study, we identified for the first time that SMYD2 methylates p53 at K370 and inhibits the transcriptional activity of p53."
34015314
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"On the other hand, the mono-methylation of p53 by Su(var), Enhancer of zeste, Trithorax 8 (SET8) and the SET domain-dependent methyltransferase subfamily (SMYD2) at K382 and K370, respectively, attenuate the transcriptional regulation activity of p53 [47,48]."
35563397
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"P53 is methylated by SMYD2 on lysine 370 (K370me1/me2); this modification is required for its association with the co-activator p53 Binding Protein 1 (53BP1) [ xref , xref ]."
30866496
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"It has been reported that SMYD2 methylates p53 at Lys-370 to decrease its binding to the promoters of target genes."
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"For example, SMYD2 methylates p53 (TP53; on lysine 370) which reduces its DNA-binding affinity and represses p53-mediated transcriptional regulation ( Tracy et al., 2018 )."
36191822
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"It has been reported that the methyltransferase SMYD2 could methylate p53 at K370 in cancer cells xref ."
30926778
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"It is proposed that SMYD2 suppressed p53-dependent apoptosis by methylating the p53 transcription factor at lysine 370 in cardiomyocytes, as shown in Figure 6 [103]."
36838987
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"It has been reported that SMYD2 monomethylates p53 at Lys370, which led to p53 inactivation by decreasing the binding activity of p53 to its target genes[22]."
36157542
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"P53 is methylated by the HMT SMYD2 at lysine K370."
37894343
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"SMYD2 also methylates non-histone targets, for example, SMYD2 mono-methylates K370 in p53 to reduce the DNA-binding efficiency of p53 [21], and this protein also methylates K810 of RB1 or K313 of PTEN to enhance cell cycle progression or inactivate tumor suppression function of PTEN, respectively [29, 30]."
37673879
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"LLY-507 Inhibits SMYD2 mediated Methylation of p53 Lys 370 in Cells."
25825497
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"SMYD2 monomethylates Lys-370 of p53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53."
31106145
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"P53 can also be methylated at K382 by Set8 or K370 by SMYD2, both of which negatively stabilize p53 (Huang et al., 2006; Shi et al., 2007)."
35685623
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"Wang demonstrated that SMYD2 can methylate p53 at site K370 thereby inhibiting its transcriptional activity which promotes CC occurrence dependent on aerobic glycolysis xref ."
38577616
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"SMYD2 can also methylate p53 at K370 to decrease p53 binding to the promoter of its target genes, thus repressing p53-mediated transcription ( xref ."
31282934
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"SMYD2 also methylates p53 at lysine-370, providing regulatory cross-talk between PTM and tumor-suppressive function (12)."
37315132
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"In this regard, it has been reported that SMYD2 can methylate p53 on Lys 370 and that this methylation leads to repression of its activity. xref As p21 is also a key mediator of p53-dependent cell cycle arrest, SMYD2-mediated p53 methylation and inactivation may decrease expression of p21 expression, thereby increasing activation of CDK4 and CDK6 and expression of cyclinD1, promoting cell cycle progression."
34143514
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"Although methylation by Smyd2 at p53 site K370 results in an inhibitory effect of p53 activity, dimethylation at this same site promotes the interaction of 53BP1 binding cofactor resulting in enhanced transcriptional activity and protein expression of puma, MDM2, and p21 upon adriamycin treatment [ xref ]."
33932560
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"In addition to histone methylation, accumulating evidence has demonstrated that non-histone proteins can also be methylated by histone methyltransferases, for example, histone methyltransferase SMYD2 mono-methylates K370 site of P53 in tumor cells [ xref , xref , xref ]."
38057834
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"It was also reported that SMYD2 can methylate lys370 of p53, and consequently promotes tumor progression [24]."
30319138
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"It has been reported that the methyltransferase SMYD2 could methylate p53 at K370 in cancer cells ."
30926778
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"SMYD2 can also methylate p53 at K370 to decrease p53 binding to the promoter of its target genes, thus repressing p53-mediated transcription (Huang et al., 2006)."
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