IndraLab
Statements
sparser
"In this regard, it has been reported that SMYD2 can methylate p53 on Lys 370 and that this methylation leads to repression of its activity. xref As p21 is also a key mediator of p53-dependent cell cycle arrest, SMYD2-mediated p53 methylation and inactivation may decrease expression of p21 expression, thereby increasing activation of CDK4 and CDK6 and expression of cyclinD1, promoting cell cycle progression."
sparser
"Although methylation by Smyd2 at p53 site K370 results in an inhibitory effect of p53 activity, dimethylation at this same site promotes the interaction of 53BP1 binding cofactor resulting in enhanced transcriptional activity and protein expression of puma, MDM2, and p21 upon adriamycin treatment [ xref ]."