IndraLab

Statements


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reach
"High dose of hypochlorous acid and tofacitinib reduce lesions and itch in the murine NC/Nga model of AD."

reach
"The dose selection for tofacitinib was according to a former study in which 0.5% tofacitinib inhibited itch behaviour and inflammation in a mouse model of allergic contact dermatitis, higher doses (when given in acetone) led to irritation of mouse skin, thus it was decided to select a concentration of 0.5% [XREF_BIBR]."

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"Tofacitinib significantly reduced itch vs. placebo (P < 0.05 both doses) and etanercept (P < 0.0001 both doses) within 1 day of starting treatment."

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"Tofacitinib may inhibit psoriatic itch through inhibition of cytokine expression as well as modulation of epidermal innervation."