IndraLab

Statements

CDK phosphorylates USP17L2. 2 / 2
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"In particular, it has been demonstrated that both these CDKs can bind and phosphorylate the deubiquitinase USP51 and DUB3, to control ZEB1 [ xref ] and SNAIL1 [ xref ] expression, respectively, thereby modulating the metastatic phenotype of cancer cells."
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"Importantly, it has been shown recently in breast cancer cells that DUB3 can be phosphorylated by CYCLIN-dependent kinases 4 and 6 (CDK4/6) and this phosphorylation is essential for the deubiquitinase activity of DUB3 ( xref ), highlighting that DUB3 is a druggable target for cancer therapy."
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