IndraLab

Statements

USP1 activates PCNA. 7 / 8
| 7
reach
"Whereas UAF1 displays no detectable activity, and isolated Usp1 shows only low levels of activity toward PCNA-Ub, stoichiometric mixtures of Usp1 and UAF1 are highly active, confirming that the PCNA-Ub can be targeted by Usp1 and UAF1 (XREF_FIG)."
22989887
reach
"In addition, DUBs involved in DNA damage signaling are USP1 that targets PCNA (proliferating cell nuclear antigen) [76], FANCD2 and FANCI (the Fanconi anemia proteins) [93,94], and USP3 and USP16 that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21763684
reach
"Because USP1 is reported to target PCNA and FANCD2 during DNA repair (Nijman et al., 2005; Huang et al., 2006), we also checked if USP1 knockdown produced DNA damage."
21925315
reach
"It has been reported that USP1 depletion from Rad18 deficient cells induces PCNA monoubiqutinatiton, indicating that other E3 ubiquitin ligase (s) carry out this function independent of Rad18."
20129063
reach
"Similar results have been seen in the case of Usp1 and Uaf -1 where knockdown of either protein alone altered the ubiquitination status of Usp1 targets PCNA and FANCD2, in this example an epistatic relationship between Usp1 and Uaf-1 was observed [XREF_BIBR]."
26462181
reach
"USP1 also targets PCNA during replication stress."
30257459
reach
"Further studies may reveal additional layers of specificity for substrates such as PCNA-Ub, which could also be mediated by the N-terminus of USP1–UAF1."
30456385