IndraLab

Statements

USP15 activates TGFBR. 3 / 5
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reach
"USP15 is known to promote stabilization of the TGF-beta receptor and its downstream signal transducers, known as receptor activated SMADS (R-SMADS), thus empowering the TGF-beta signaling [XREF_BIBR, XREF_BIBR]."
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reach
"Both USP15 and USP4 stimulate TGF-beta signaling by deubiquitylating and stabilizing two key signaling molecules in this pathway, TGF-beta receptor I (TbetaRI) and R-SMADs, suggesting that these two closely related DUBs act in concert to modulate central signaling processes that are involved in oncogenesis and innate immunity."
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"For example, USP15 promotes the stabilization of TGF-β receptor and its downstream signal transducers, thereby resulting in enhanced TGF-β signaling[13,36]."
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