IndraLab

Statements

USP1 activates DNA repair. 6 / 6
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"Usp1 modulates DNA replication, polymerase choice and DNA repair by PCNA and as a result Usp1 knock-out mice are genetically unstable and hypersensitive to DNA damage [XREF_BIBR], [XREF_BIBR]."
25962961
eidos
"As another example of genes involved in DNA damage , Usp1 is a key modulator of DNA repair , partly through de-ubiquitination of its known targets such as FANCD2 ( Oestergaard et al ., 2007 ) and PCNA ( T. T. Huang et al ., 2006 ) ."
33469999
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"The deubiquitinating enzyme, USP1 is known to promote DNA repair via complexing with UAF1."
25972987
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"As another example of genes involved in DNA damage, Usp1 is a key modulator of DNA repair, partly through de-ubiquitination of its known targets such as FANCD2 (Oestergaard et al., 2007) and PCNA (T. T. Huang et al., 2006)."
33469999
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"Because CHK1 is a cell cycle regulated and DNA damage checkpoint protein, we asked whether (a) the downregulation of CHK1 in USP1 depleted cells is an experimental artefact resulting from modifications of the cell cycle and/or altered DNA repair capabilities caused by USP1 depletion and (b) USP1 depletion modifies the G2 checkpoint in response to DNA damage."
21389083
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"Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells."
28270494