IndraLab

Statements

NEDD4L ubiquitinates SCN9A. 5 / 5
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ubibrowser
No evidence text available
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
reach
"We will also discuss more recent findings that the ubiquitination of Nav1.7 by Nedd4-2 and the effect of methylglyoxal on Nav1.8 are also implicated in the development of experimental neuropathic pain."
26594175
sparser
"Therefore, NEDD4-2 can ubiquitinate Nav1.7 and Nav1.8 and then regulate the ion channel of the cell membrane ( xref )."
34122010
ubibrowser
"UbiNet 2.0"
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