IndraLab

Statements

USP28 activates cell cycle. 11 / 11
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"Further, we found that USP28 promoted PC cell growth by facilitating cell cycle progression and inhibiting apoptosis."
34584067
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"Our results furthermore explain how USP28 may modulate the p53 dependent cell cycle checkpoint, thereby controlling tumor cell fate decisions as previously described."
31982308
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"Therefore, mediated by LSD1, USP28 can accelerate the cell cycle and promote cell proliferation."
36879346
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"53BP1 and USP28 mediate p53 dependent cell cycle arrest in response to centrosome loss and prolonged mitosis."
27371829
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"USP28 and SPINT2 mediate cell cycle arrest after whole genomedoubling."
| DOI
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"In addition to promoting the cell cycle and enhancing aerobic glycolysis, USP28 can also stimulate cell proliferation."
36879346
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"Similarly, western blot analyses revealed that the total p53 levels in 53BP1 -/- or USP28 -/- cells were kept low during acentrosomal cell division in the presence of mitotic delay (XREF_FIG), indicating that 53BP1 and USP28 function upstream of p53 to initiate cell cycle arrest in response to centrosome loss."
27371829
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"Consistently, overexpression of the wild type USP28 but not USP28 CI in normal, unstressed cells caused ectopic nuclear p53 accumulation and cell cycle arrest uniformly across the entire population (100%, XREF_FIG; not shown)."
27371829
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"In addition to arresting centrosome deficient cells, p53, 53BP1, and USP28 are all involved in the DNA damage response (DDR), raising the possibility that centrosome loss causes a cell cycle arrest because it somehow induces DNA damage."
| PMC
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"We showed that 53BP1 and USP28 are required to trigger p53 and p21- dependent cell cycle arrest, evoking an irreversible stress response that selects against unfit cells with disturbed mitosis (XREF_FIG)."
27371829
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"Although the functions of ΔNp63 are independent of p53, these results indicate that USP28 promotes the cell cycle through its impacts on ΔNp63 and then accelerates cell proliferation."
36879346