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PSMD14 inhibits SF3B4. 3 / 3
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"Consistent with this work, we observed that PSMD14 only reduced the polyubiquitin chain connected to K63 on SF3B4 in TNBC cells, altering the form of SF3B4 oligomers to regulate the stability of SF3B4 protein."
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"PSMD14 down-regulation induced proteasome degradation of SF3B4 (Fig. 4D)."
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"PSMD14 down-regulation reduced SF3B4 protein half-life, but PSMD14 overexpression elevated SF3B4 stability after using cycloheximide (CHX) to inhibit protein synthesis (Fig. 4, E and F)."
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