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TNF activates SCN9A. 10 / 11
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"TNF-α up-regulated NaV1.7 mRNA in both adrenal chromaffin cells and DRG neurons."
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"In addition, TNF-α up-regulated the protein expression of the TTX-S NaV1.7 channel in adrenal chromaffin cells."
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"In cultured DRG neurons, TNF-α dose-dependently upregulates Nav1.3, Nav1.8 and Nav1.7 ( He et al., 2010; Tamura et al., 2014 )."
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"These data suggest that increased TNF-α may be responsible for up-regulation of Nav1.7 in DRG neurons of rats with DN, and NF-κB signal pathway is possibly involved in this process.Male Sprafue-Dawley[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In cultured DRG neurons, TNF-α upregulates Nav1.3, Nav1.8 and Nav1.7 in a dose-dependent manner ( Chen et al., 2011; He et al., 2010; Tamura et al., 2014 )."
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"These data suggest that increased TNF-α may be responsible for up-regulation of Nav1.7 in DRG neurons of rats with DN, and NF-κB signal pathway is possibly involved in this process.In rodents, symptom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TNF-α treatment induced a significant upregulation of Nav1.6 and Nav1.7 (Figure 6, C–G)."
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"Importantly, increased TNF-α in DRG may be responsible for up-regulation of Nav1.7 in rats with DN, and NF-κB signal pathway may be involved in this process."
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"TNF-α up-regulated NaV1.7 mRNA by 132% ± 9% (N = 5, P = 0.004) in adrenal chromaffin cells, as well as 117% ± 2% (N = 5, P < 0.0001) in DRG neurons."
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"Western blot analysis showed that TNF-α increased NaV1.7 protein up to 166% ± 24% (N = 5, corrected P < 0.0001) in adrenal chromaffin cells, concentration- and time-dependently."
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