IndraLab

Statements

USP12 binds AR. 11 / 11
3 | 3 5
sparser
"Although we were able to confirm the USP12- AR FL interaction we could not detect any interaction between USP12 and AR V7 (Figure xref )."
29861848
sparser
"To validate this result we overexpressed USP12 with AR FL, N-terminus of AR (AR ND) and AR N-terminus with DNA binding domain (AR ND-DNA BD) to localise the USP12-AR interaction."
29861848
reach
"The requirement of the AR ligand binding domain to ensure an interaction between USP12 and AR is supported by our results in Figure XREF_FIG showing that AR FL is stabilised following USP12 overexpression whereas the AR V7 proteins levels are unaffected."
29861848
sparser
"The requirement of the AR ligand binding domain to ensure an interaction between USP12 and AR is supported by our results in Figure xref showing that AR FL is stabilised following USP12 overexpression whereas the AR V7 proteins levels are unaffected (Figure xref )."
29861848
sparser
"Usp12 was capable of interacting with both AR S213A and AR S213A/S791A with comparable efficiency to wild-type confirming that these sites are not required for this interaction (Figure xref )."
25216524
biogrid
No evidence text available
25216524
biogrid
No evidence text available
24056413
reach
"To investigate if this was caused by the lack of interaction between AR and Usp12 in the absence of the specific serine residues, we overexpressed Usp12 alongside wild-type and mutant ARs followed by immunoprecipitation."
25216524
reach
"We have recently reported that Usp12, in complex with Uaf-1 and WDR20, can directly bind and deubiquitinate the AR resulting in increased receptor stability and transcriptional activity [XREF_BIBR]."
25216524
biogrid
No evidence text available
26462181
sparser
"To investigate if this was caused by the lack of interaction between AR and Usp12 in the absence of the specific serine residues, we overexpressed Usp12 alongside wild-type and mutant ARs followed by immunoprecipitation."
25216524