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CYLD binds BCL3. 31 / 32
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"In contrast, wild-type keratinocytes have reduced proliferation rates compared to the knockout cells due to the interaction of BCL3 with CYLD in the cytoplasm, where removal of K63 ubiquitin chains by CYLD occurs [ xref ]."
22235375
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"The increased tumour incidence was attributed to the loss of an inhibitory interaction between CYLD and the proto-oncogene Bcl-3."
19893491
reach
"The colocalization of Cyld and Bcl-3 in the perinuclear region of TPA- or UV-B-treated keratinocytes suggested that Cyld may associate with Bcl-3 and regulate its activity."
16713561
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"In addition to cell motility, HDAC6 regulates the cell cycle through deacetylating α-tubulin and promoting the interaction of CYLD and BCL3 [ xref , xref ] (Fig.  xref )."
30176876
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"CYLD physically interacts with Bcl3 through a specific region that is different from the domain that mediates binding to TRAF2 and NEMO. xref CYLD inhibits K63-linked ubiquitination and nuclear translocation of Bcl3, thus suggesting a role for ubiquitination in the regulation of Bcl3 nuclear expression ( xref )."
19373246
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"HDAC6 inactivation promotes an increase in the cellular levels of acetylated tubulin surrounding the perinuclear region and facilitates the association of CYLD with its downstream substrate, B-cell CL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347313
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No evidence text available
19893491
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"In our experiments, the inhibitory effect of CYLD on the nuclear accumulation of phosphorylated STAT3 resembles CYLD-Bcl3 interaction, since CYLD also deubiquitinates Bcl-3 in perinuclear regions and prevents its translocation to the nucleus, a process which significantly contributes to the development of keratinocyte hyperproliferation and development of benign tumors of the skin appendage called cylindromatosis xref ."
23825949
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"To examine whether the interaction between Cyld and Bcl-3 is achieved through a direct or an indirect interaction, we performed yeast two-hybrid assays."
16713561
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"In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation."
16713561
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"These assays revealed that full length Bcl-3 indeed interacted with Cyld and that the binding site for Bcl-3 on Cyld corresponded to the C-terminal part of the protein."
16713561
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"These assays revealed that full length Bcl-3 indeed interacted with Cyld and that the binding site for Bcl-3 on Cyld corresponded to the C-terminal part of the protein (D and )."
16713561
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"This is supported by the finding that depletion of HDAC6 was not sufficient to induce the interaction of CYLD with Bcl-3, but TPA-mediated activation of CYLD is additionally required."
19893491
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"It has been found that HDAC6 is highly expressed in melanoma, and by knocking down HDAC6 acetylated α-microtubulin increases, acetylated microtubules accumulate, causing CYLD to get around the nucleus, ultimately leading to a reduction in the interaction between CYLD and BCL3, preventing the transcriptional activity of the nuclear factor NF-κB, which in turn affects cell growth and metastasis.Immunomodulation is of interest as a new idea in cancer therapy, especially in tumors lacking specific molecular targets."
34485153
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"When HDAC6 is silenced or knocked down, acetylated α-tubulin is increased, acetylated MTs are accumulated, and CYLD is translocated to the perinuclear region, leading to a reduced interaction between CYLD and BCL3 [ xref , xref , xref ]."
30176876
reach
"CYLD physically interacts with Bcl3 through a specific region that is different from the domain that mediates binding to TRAF2 and NEMO."
19373246
sparser
"Although both the full-length and the mutant CYLD are able to interact with Bcl-3, a predominant nuclear accumulation of Bcl-3 occurs in the CYLD mutant B cells."
17923499
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"S4, B and C), whereas a catalytically inactive mutant of CYLD (CYLD C/S) still binding to BCL-3 was unable to prevent nuclear translocation (Fig. S4, C and D)."
19124656
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"Mechanistically, the in vitro results showed that Bcl-3 interacted with the deubiquitinase CYLD to synergistically switch the ubiquitination status of RIP1 and facilitate the formation of death-inducing Complex II."
34853447
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"These data supports a model in which TPA or UV-B treatment leads to the translocation of Cyld to the perinuclear region, where Cyld binds Bcl-3 and inhibits its nuclear accumulation."
16713561
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"As for CYLD, studies have shown that CYLD binds to and deubiquitylates BCL-3 inhibiting its nuclear translocation, leading to decreased transcription of CCND, and delayed cells from entering S-phase 35."
33654169
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"The association of CYLD with Bcl-3, which results from activation and subsequent perinuclear translocation of the protein, leads to the removal of a lysine 63-linked ubiquitin chain from Bcl-3, which in turn inhibits the nuclear translocation and activity of Bcl-3 ( xref )."
19893491
sparser
"This facilitates the interaction of CYLD with Bcl-3, leading to a significant delay in the G 1 -to-S-phase transition."
19893491
sparser
"The colocalization of Cyld and Bcl-3 in the perinuclear region of TPA- or UV-B-treated keratinocytes suggested that Cyld may associate with Bcl-3 and regulate its activity."
16713561
sparser
"As for CYLD, studies have shown that CYLD binds to and deubiquitylates BCL-3 inhibiting its nuclear translocation, leading to decreased transcription of CCND, and delayed cells from entering S-phase xref ."
33654169
sparser
"However, TSA treatment or HDAC6 depletion alone did not induce interaction of CYLD with Bcl-3 ( xref )."
19893491
sparser
"To examine whether the interaction between Cyld and Bcl-3 is achieved through a direct or an indirect interaction, we performed yeast two-hybrid assays."
16713561
reach
"In Cyld +/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50 and Bcl-3- or p52 and Bcl-3-dependent proliferation."
16713561
sparser
"Coimmunoprecipitation experiments in primary keratinocytes revealed that TPA facilitated the association of endogenous Cyld with endogenous Bcl-3 already 15 min after TPA treatment (C)."
16713561
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"9 In this study, we also assessed the association of Bcl-3 and CYLD in VSMCs."
18245814
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"These data supports a model in which TPA or UV-B treatment leads to the translocation of Cyld to the perinuclear region, where Cyld binds Bcl-3 and inhibits its nuclear accumulation."
16713561