IndraLab

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Cyclic peptide inhibits UCHL5. 5 / 5
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"Taken together, our data suggest that the cyclic peptide permeates the cell membrane, inhibits UCH-L5 by possibly blocking its deubiquitinating function, and contributes to the accumulation of polyubiquitinated substrates."
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eidos
"Taken together , our data suggest that the cyclic peptide permeates the cell membrane , inhibits UCH-L5 by possibly blocking its deubiquitinating function , and contributes to the accumulation of polyubiquitinated substrates ."
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"We observed that the cyclic peptide inhibited UCH-L5 at lower micromolar concentrations compared to other DUBs in the UCH family even though they share a similar binding mode to Ub."
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"Moreover, we show that the treatment of cells with our cyclic peptide results in the accumulation of ubiquitinated substrates without any toxicity on the cells caused by the peptide, suggesting that the cyclic peptide permeates the cell membrane and potentially inhibits the activity of UCH-L5."
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"Taken together with the previous data from IC assays, activity-based competition assays, and the activity-based DUB profiling, we showed that the cyclic peptide 2 preferably inhibited UCH-L5 compared to other DUBs in the UCH family and did not show a significant effect on the probe-labeling of other DUBs in MCF7 cell lysate."
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