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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CDK4 leads to the phosphorylation of RB1 on T821. 1 / 1

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"We found that Costello syndrome fibroblasts display elevated level of Rb phosphorylation on serine 780 (Ser (P)-780-Rb) and that pharmacological inhibition of Ras with radicicol, Mek and Erk with PD98059, or cyclin dependent kinase 4 with PD0332991 not only leads to down-regulation of Ser (P)-780-Rb levels but also enhances Rb phosphorylation on threonine 821 (Thr (P)-821-Rb), which coincides with the recovery of elastin production."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...