IndraLab

Statements

MDM2 inhibits TP53. 6 / 6
3 3 |
bel
"Furthermore, by coimmunoprecipitaton and cotransfection assays, we found that PTEN physically binds p53 in vitro as well as in vivo. Binding of PTEN to p53 attenuated MDM2-mediated p53 inhibition."
14559824
bel
"Upregulation of IGF-1 in myocytes was associated with a protein-to-protein interaction between Mdm2 and p53, which attenuated p53 transcriptional activity for bax, Aogen, and AT1 receptor. Similarly, the amount of Bax, Aogen, and AT1 receptor proteins in these cells decreased"
10205143
bel
"<p29> mdm2 inhibits p53-mediated transactivation; it inhibits the expression of p53 dependent genes"
10436023
bel
"Upregulation of IGF-1 in myocytes was associated with a protein-to-protein interaction between Mdm2 and p53, which attenuated p53 transcriptional activity for bax, Aogen, and AT1 receptor. Similarly, the amount of Bax, Aogen, and AT1 receptor proteins in these cells decreased"
10205143
bel
"<p29> mdm2 inhibits p53-mediated transactivation; it inhibits the expression of p53 dependent genes"
10436023
bel
"Furthermore, by coimmunoprecipitaton and cotransfection assays, we found that PTEN physically binds p53 in vitro as well as in vivo. Binding of PTEN to p53 attenuated MDM2-mediated p53 inhibition."
14559824