IndraLab

Statements

Spautin-1 inhibits USP13. 21 / 21
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"Spautin-1 inhibits the catalytic activity of both USP10 and USP13 with an IC 50 of ~ 0.6-0.7 microM."
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"Spautin-1 inhibits autophagy by reducing the activity of USP10 and USP13, which promotes a major aspect of autophagy: degradation by Vps34 complexes."
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"Spautin-1 promotes the degradation of PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3, also termed Vps34 in yeast) complexes by inhibiting USP10 (ubiquitin specific peptidase 10) and USP13 (ubiquitin specific peptidase 13)."
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"Spautin-1 inhibits USP10 and USP13, two deubiquitinating enzymes that regulate the stability of BECN1, a key autophagy protein [291]."
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"Spautin-1 was shown to inhibit USP-13, a de-ubiquitinase of the host cell hijacked by the SARS-CoV-2 which led to successful ubiquitination of nsp-13 [109]."
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"In both HeLa and SiHa cells , inhibition of USP13 by Spautin-1 resulted in a dose-dependent decrease in Mcl-1 protein expression ( Fig. 8A ) ."
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"Spautin-1, which effectively inhibits two ubiquitin-specific peptidases, USP10 and USP13, that target Beclin-1, was reportedly shown to effectively inhibit autophagy [17] ."
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"Spautin-1 also reduced USP13 expression , as has been previously observed in other cell lines ( Fig. 8A ) ."
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"Spautin-1 inhibits the activity of two ubiquitin specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy [XREF_BIBR]."
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"Moreover, treatment of Spautin-1 almost abolished the ability of USP13 to cleave ubiquitin moieties from polyubiquitinated METTL3 in 143B cells and HEK 293T cells (Fig. 8c, d)."
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"Pharmacologic inhibition of USP13 by Spautin-1, a small-molecule inhibitor of USP13, showed therapeutic effects on OS."
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"Spautin-1 can suppress USP13 and is reported as an inhibitor of the early-stage autophagy [51]."
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"Spautin-1 is an autophagy inhibitor and can induce the degradation of the Vps34 PI3 complex by suppressing USP10 and USP13 (two ubiquitin-specific peptidases) [92]."
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"Spautin-1 inhibits the ubiquitin-specific peptidases USP10 and USP13 that are necessary to initiate autophagosome formation [49]; MRT68921 targets the protein kinases ULK1/2, which are catalytic components of the autophagy pre-initiation complex [50]."
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"Spautin-1 inhibits ubiquitin specific peptidases, USP10 and USP13, and promotes the degradation of Vps34-PI3 kinase complexes, key regulators of autophagy, leading to inhibition of autophagy."
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"In both HeLa and SiHa cells, inhibition of USP13 by Spautin-1 resulted in a dose dependent decrease in Mcl-1 protein expression."
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"A study by Liu et al. (Liu et al., 2011) has demonstrated that Spautin-1 is a potent small-molecule inhibitor of USP10 and USP13, and treatment with Spautin-1 inhibits the deubiquitinase activity of USP10 and USP13, resulting in an increasing ubiquitination and accelerating degradation of Beclin1 in Vps34 complexes, ultimately inhibiting autophagy."
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"Molecular analysis revealed that Spautin-1 directly inhibits the activity of the deubiquitinating enzymes (DUBs) ubiquitin specific protease 10 (USP10) and USP13."
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"Indeed, a recent study showed that a small molecule, Spautin-1, promoted the degradation of Vps34 by inhibiting two ubiquitin specific proteases USP10 and USP13 that regulate the stability of the Vps34 complex [XREF_BIBR]."
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"Spautin-1 inhibits the ubiquitin proteases USP10 and USP13, which remove ubiquitin from Beclin1."
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"Spautin-1 inhibits the activity of the deubiquitinating enzymes USP13 and USP10."
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