IndraLab

Statements

Spautin-1 inhibits USP13. 12 / 12
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"Spautin-1 inhibits the activity of the deubiquitinating enzymes USP13 and USP10."
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"Spautin-1 inhibits the catalytic activity of both USP10 and USP13 with an IC 50 of ~ 0.6-0.7 microM."
30126257
tas
No evidence text available
25364867
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"Spautin-1 inhibits the activity of two ubiquitin specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy [XREF_BIBR]."
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"Spautin-1 promotes the degradation of PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3, also termed Vps34 in yeast) complexes by inhibiting USP10 (ubiquitin specific peptidase 10) and USP13 (ubiquitin specific peptidase 13)."
29872558
eidos
"Spautin-1 also reduced USP13 expression , as has been previously observed in other cell lines ( Fig. 8A ) ."
33627786
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"Indeed, a recent study showed that a small molecule, Spautin-1, promoted the degradation of Vps34 by inhibiting two ubiquitin specific proteases USP10 and USP13 that regulate the stability of the Vps34 complex [XREF_BIBR]."
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"Spautin-1 inhibits ubiquitin specific peptidases, USP10 and USP13, and promotes the degradation of Vps34-PI3 kinase complexes, key regulators of autophagy, leading to inhibition of autophagy."
26732534
eidos
"In both HeLa and SiHa cells , inhibition of USP13 by Spautin-1 resulted in a dose-dependent decrease in Mcl-1 protein expression ( Fig. 8A ) ."
33627786
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"58 Spautin-1 promotes the degradation of BECN1 by inhibiting 2 USPs (ubiquitin-specific peptidases), USP10 and USP13, which target BECN1."
27541856
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"Molecular analysis revealed that Spautin-1 directly inhibits the activity of the deubiquitinating enzymes (DUBs) ubiquitin specific protease 10 (USP10) and USP13."
25545884
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"In both HeLa and SiHa cells, inhibition of USP13 by Spautin-1 resulted in a dose dependent decrease in Mcl-1 protein expression."
33627786